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TRPM1 is required for the depolarizing light response in retinal ON-bipolar cells
TLDR
Identification of TRPM1 as a mGluR6-coupled cation channel reveals a key step in vision, expands the role of the TRP channel family in sensory perception, and presents insights into the evolution of vertebrate vision.
Glutamate Transporter Studies Reveal the Pruning of Metabotropic Glutamate Receptors and Absence of AMPA Receptor Desensitization at Mature Calyx of Held Synapses
TLDR
It is suggested that diffusion and transporter activation are insufficient to clear synaptically released glutamate at immature calyces, resulting in significant desensitization, and mGluRs may be expressed in the immature calyx to help limit glutamate release.
Localization of mGluR6 to dendrites of ON bipolar cells in primate retina
TLDR
The patterns of immunostaining in retina of monkey, cat, and rabbit suggest that all types of ON bipolar cells, despite their marked differences in function, express a single isoform of mGluR6.
Increased Seizure Susceptibility in Mice Lacking Metabotropic Glutamate Receptor 7
TLDR
It is suggested that mGluR7 receptors have a unique role in regulating neuronal excitability and that these receptors may be a novel target for the development of anticonvulsant drugs.
A function for lipoxygenase in programmed organelle degradation
TLDR
The action of 15-LOX provides a mechanism by which the natural degradation process can be explained and is supported by the finding that lipoxygenase expression in the eye lens is restricted to the region at which organelle degradation occurs.
Retroinhibition of Presynaptic Ca2+ Currents by Endocannabinoids Released via Postsynaptic mGluR Activation at a Calyx Synapse
TLDR
The data suggest that activation of postsynaptic mGluRs triggers the Ca2-dependent release of endocannabinoids that activate CB1 receptors on the calyx terminal, which leads to a reduction of presynaptic Ca2+ current and glutamate release.
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