mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
The results demonstrate that the effects of ketamine are opposite to the synaptic deficits that result from exposure to stress and could contribute to the fast antidepressant actions of ketamines.
Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus
- J. Malberg, A. Eisch, E. Nestler, R. Duman
- Biology, PsychologyJournal of Neuroscience
- 15 December 2000
Investigation of the effect of antidepressants on hippocampal neurogenesis in the adult rat using the thymidine analog bromodeoxyuridine (BrdU) as a marker for dividing cells demonstrates that chronic antidepressant treatment significantly increases the number of BrdU-labeled cells in the dentate gyrus and hilus of the hippocampus.
A Neurotrophic Model for Stress-Related Mood Disorders
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms
Greater appreciation of the convergence of mechanisms between stress, depression, and neuroplasticity is likely to lead to the identification of novel targets for more efficacious treatments.
A molecular and cellular theory of depression.
These findings constitute the framework for an updated molecular and cellular hypothesis of depression, which posits that stress-induced vulnerability and the therapeutic action of antidepressant treatments occur via intracellular mechanisms that decrease or increase, respectively, neurotrophic factors necessary for the survival and function of particular neurons.
Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications
Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure
IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress
It is demonstrated that in vivo and in vitro studies demonstrate that hippocampal neural progenitor cells express IL-1RI and that activation of this receptor decreases cell proliferation via the nuclear factor-κB signaling pathway, a critical mediator of the antineurogenic and depressive-like behavior caused by acute and chronic stress.
Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression
- Y. Shirayama, A. C. Chen, S. Nakagawa, D. Russell, R. Duman
- Psychology, BiologyJournal of Neuroscience
- 15 April 2002
The hypothesis that BDNF in the hippocampus produces an antidepressant effect in behavioral models of depression, the learned helplessness (LH) and forced swim test (FST) paradigms is tested and provides further support for the hypothesis thatBDNF contributes to the therapeutic action of antidepressant treatment.