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Clinical Pharmacokinetics of Aminoglycoside Antibiotics
SummaryThe pharmacokinetics of widely used and of investigated aminoglycosides, namely kanamycin, gentamicin, tobramycin, amikacin, sisomicin and netilmicin, in normal volunteers and in patients with…
Studies on anabolic steroids. I. Integrated methodological approach to the gas chromatographic-mass spectrometric analysis of anabolic steroid metabolites in urine.
Comprehensive screening procedure for diuretics in urine by high-performance liquid chromatography.
Pharmacokinetics of intravenously administered tobramycin in normal volunteers and in renal-impaired and hemodialyzed patients.
The pharmacokinetics of intravenously administered tobramycin, an aminoglycoside antibiotic, were studied in 16 volunteers with normal renal function and 10 patients with different degrees of renal impairment, and the elimination rate constant decreased proportionally with increasing degree of kidney impairment.
Distribution and elimination kinetics of intravenously and intramusculary administered tobramycin in man.
- J. Pechère, B. Roy, R. Dugal
- Medicine, BiologyInternational journal of clinical pharmacology…
- 1 December 1976
The pharmacokinetic profile of Tobramycin, a new aminoglycoside antibiotic, has been determined in man following intravenous and intramuscular administration and a method of administration compatible with the kinetic properties of the drug is proposed.
Determination of loxapine in human plasma and urine and identification of three urinary metabolites.
- S. Cooper, R. Dugal, M. Bertrand
- Chemistry, MedicineXenobiotica; the fate of foreign compounds in…
In addition to unchanged loxapine, three urinary metabolic products, namely aromatic ring-hydroxy loxamine, desmethyl loxabine and loxAPine-N-oxide, were identified using g.l.c.--mass spectrometry.
The Nitrogen-Phosphorus Detector in the Gas Chromatographic Assay of Unmetabolized Methylphenidate
A sensitive and specific gas chromatographic method, using the nitrogen/phosphorus (N-P) detector for the detection and quantitative determination of methylphenidate extracted from urine has been…
AES-CCM Elliptic Curve Cryptography (ECC) Cipher Suites for TLS
This memo describes the use of the Advanced Encryption Standard (AES) in the Counter and CBC-MAC Mode (CCM) of operation within Transport Layer Security (TLS) to provide confidentiality and…