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Studies on anabolic steroids. I. Integrated methodological approach to the gas chromatographic-mass spectrometric analysis of anabolic steroid metabolites in urine.
The analytical and methodological imperatives for large-scale and routine gas chromatographic-mass spectrometric screening of anabolic steroid urinary metabolites are described. Several aspects of… Expand
Clinical Pharmacokinetics of Aminoglycoside Antibiotics
SummaryThe pharmacokinetics of widely used and of investigated aminoglycosides, namely kanamycin, gentamicin, tobramycin, amikacin, sisomicin and netilmicin, in normal volunteers and in patients with… Expand
Biochemical outcome following external beam radiation therapy with or without androgen suppression therapy for clinically localized prostate cancer.
CONTEXT Combined treatment using radiation therapy (RT) and androgen suppression therapy (AST) is used to treat men with clinically localized adenocarcinoma of the prostate, but outcome using this… Expand
Comprehensive screening procedure for diuretics in urine by high-performance liquid chromatography.
A rapid and reliable screening procedure using high-performance liquid chromatography for the detection of 23 diuretics (belonging to five different pharmacological groups) in urine has been… Expand
Pharmacokinetics of intravenously administered tobramycin in normal volunteers and in renal-impaired and hemodialyzed patients.
The pharmacokinetics of intravenously administered tobramycin, an aminoglycoside antibiotic, were studied in 16 volunteers with normal renal function and 10 patients with different degrees of renal… Expand
Distribution and elimination kinetics of intravenously and intramusculary administered tobramycin in man.
The pharmacokinetic profile of Tobramycin, a new aminoglycoside antibiotic, has been determined in man following intravenous and intramuscular administration. The serum elimination of the antibiotic… Expand
Determination of loxapine in human plasma and urine and identification of three urinary metabolites.
- S. Cooper, R. Dugal, M. Bertrand
- Chemistry, Medicine
- Xenobiotica; the fate of foreign compounds in…
1. A g.l.c. method for quantitative determination of loxapine (2-chloro-11-(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)oxazepine), in human plasma and urine is described. 2. Preliminary pharmacokinetic… Expand
The Nitrogen-Phosphorus Detector in the Gas Chromatographic Assay of Unmetabolized Methylphenidate
A sensitive and specific gas chromatographic method, using the nitrogen/phosphorus (N-P) detector for the detection and quantitative determination of methylphenidate extracted from urine has been… Expand
Studies on anabolic steroids. III. Detection and characterization of stanozolol urinary metabolites in humans by gas chromatography-mass spectrometry.
The metabolism of stanozolol (17 beta-hydroxy-17 alpha-methyl-5 alpha-androstano[3,2-c]pyrazole), an androgenic-anabolic steroid widely used in sport for the purpose of enhancing performance, was… Expand