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A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
Both the thermal method and the Randall‐Selitto mechanical method detected dose‐related hyperalgesia and its blockade by either morphine or indomethacin, but the Thermal method showed greater bioassay sensitivity and allowed for the measurement of other behavioral parameters in addition to the nociceptive threshold. Expand
A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury
This preparation may serve as a model for syndromes of the causalgiform variety that are triggered by partial nerve injury and maintained by sympathetic activity, and it is suggested that these abnormalities critically depend on the sympathetic outflow. Expand
Peripheral suppression of first pain and central summation of second pain evoked by noxious heat pulses
The relationship between first and second pain and impulse conduction in A&dgr; and C noxious heat afferents, respectively and previous studies have shown that wide dynamic range dorsal horn neurons show summated responses to repeated volleys in C fibers could account for the summation of second pain. Expand
Glial–Cytokine–Neuronal Interactions Underlying the Mechanisms of Persistent Pain
Evidence is provided that demonstrates a mechanism by which glia interact with neurons, leading to activity-dependent plasticity and hyperalgesia, and the coupling of NMDA receptor phosphorylation through IL-1 receptor signaling. Expand
Characterization of basal and re-inflammation-associated long-term alteration in pain responsivity following short-lasting neonatal local inflamatory insult
These parameters in a rat model of short‐lasting (∼24 h) neonatal local inflammation of a hindpaw produced by injection of 0.25% carrageenan provide a framework within which the entire complex of long‐term effects of early noxious experience can be understood and examined. Expand
Interactions between the immune and nervous systems in pain
A greater understanding of the role of the immune system in pain processing and modulation reveals potential targets for analgesic drug development and new therapeutic opportunities for managing chronic pain. Expand
Pain measurement: an overview
The practice and theoretical basis of pain measurement is reviewed and critically examined in the areas of animal research, human subjects laboratory investigation and clinical study, and subjective report procedures are evaluated in human laboratory and clinical areas. Expand
Supraspinal Glial–Neuronal Interactions Contribute to Descending Pain Facilitation
These studies have addressed a novel contribution of supraspinal astrocytes and associated cytokines as well as central glial–neuronal interactions to the enhancement of descending facilitation of neuropathic pain. Expand
Activity-dependent neuronal plasticity following tissue injury and inflammation
A model has been proposed in which dynorphin, substance P and calcitonin gene-related peptide enhance excitability at NMDA receptor sites, leading first to dorsal horn hyperexcitability and then to excessive depolarization and excitotoxicity. Expand
Response properties and receptive fields of cells in an anatomically defined region of the superior temporal sulcus in the monkey.
A clutch brake unit suitable for use in conjunction with a heavy duty clutch assembly for retarding the motion of the driven clutch shaft. The unit is actuated by the clutch release mechanism whichExpand