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Synthesis of (S)-naproxen-benzotriazole and its application as chiral derivatizing reagent for microwave-assisted synthesis and indirect high performance liquid chromatographic separation of…
(S)-Naproxen-benzotriazole was synthesized by the reaction of (S)-naproxen with 1H-benzotriazole using coupling reagent dicyclohexyl carbodiimide and 4-dimethylamino pyridine (DCC/DMAP). It was used… Expand
Validated high-performance liquid chromatographic enantioseparation of selenomethionine using isothiocyanate based chiral derivatizing reagents.
A high-performance liquid chromatographic (HPLC) method for enantioseparation of selenomethionine (SeMet) was developed using two isothiocyanate-based chiral derivatizing reagents [(R)-methyl benzyl… Expand
Application of amino acid amides as chiral auxiliaries in difluoro dinitro benzene and cyanuric chloride moieties for high-performance liquid-chromatographic enantioseparation of selenomethionine and…
Abstractl-Ala-NH2, l-Val-NH2, l-Leu-NH2, and d-Phg-NH2 were used as chiral auxiliaries to synthesize four chiral derivatizing reagents (CDRs) of each of the three categories, viz., difluoro dinitro… Expand
Indirect reversed-phase high-performance liquid chromatographic and direct thin-layer chromatographic enantioresolution of (R,S)-Cinacalcet.
Enantioresolution of the calcimimetic drug (R,S)-Cinacalcet was achieved using both indirect and direct approaches. Six chiral variants of Marfey's reagent having L-Ala-NH(2), L-Phe-NH(2),… Expand
Normal and polar-organic-phase high-performance liquid chromatographic enantioresolution of omeprazole, rabeprazole, lansoprazole and pantoprazole using monochloro-methylated cellulose-based chiral…
Enantioresolution of four anti-ulcer drugs (chiral sulfoxides), namely, omeprazole, rabeprazole, lansoprazole and pantoprazole, was carried out by high-performance liquid chromatography using a… Expand
Integrated lab-on-chip and mass spectrometry: recent advances in bioanalysis.
Microcontact printing in bioanalysis: where are we and where shall we be?
Since the inception of microcontact printing (μCP) in early 1990s by Whitesides and coworkers [1,2] to control protein adsorption on cell culture surfaces, it has nowadays covered the widest picture… Expand
High-performance liquid chromatography for analytical and small-scale preparative separation of (R,S)-mexiletine using (S)-(—)-(N)-trifluoroacetyl-prolyl chloride and (1S)-(—)-camphanic chloride and…
A reversed phase high-performance liquid chromatographic method has been established for enantioseparation of (R, S)-mexiletine. Two volatile and thermally stable acyl chlorides, viz.,… Expand
Enantioseparation by Thin-Layer Chromatography.
Despite the fact that high-performance liquid chromatography is the predominant technique for analytical and preparative enantioseparations, chiral thin-layer chromatography (TLC) may represent an… Expand
A Rapid, Robust and Ultra-Sensitive HPLC Enantioseparation of β-Amino Alcohols.
Enantioseparation of amino acid analogues racemic β-amino alcohols has hitherto been thought impossible without prior derivatization. Method developers of chromatographic enantioseparation often face… Expand