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Cyclooxygenase in biology and disease
TLDR
The current understanding of the role of cyclooxygenase‐1 and ‐2 in different physiological situations and disease processes ranging from inflammation to cancer is summarized.
Eicosanoids and cancer
TLDR
Understanding the molecular mechanisms underlying the role of prostaglandins and other eicosanoids in cancer progression will help to develop more effective cancer chemopreventive and/or therapeutic agents.
The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis.
TLDR
In patients with familial adenomatous polyposis, six months of twice-daily treatment with 400 mg of celecoxib, a cyclooxygenase-2 inhibitor, leads to a significant reduction in the number of colorectal polyps.
Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells.
TLDR
It is reported that PGE2 treatment of human colon cancer cells leads to increased clonogenicity of HCA-7, but not HCT-116 cells, which may help to explain a component of the mechanism by which COX inhibitors prevent colorectal cancer in humans.
The role of cyclooxygenases in inflammation, cancer, and development
TLDR
Offspring from cox-2 null by ApcΔ716 matings exhibit an 86% reduction in polyp number when compared to offspring from control animals, thus providing genetic evidence that COX-2 contributes to tumor formation or growth.
Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential.
TLDR
It is demonstrated that constitutive expression of COX-2 can lead to phenotypic changes that alter the metastatic potential of colorectal cancer cells and be reversed by treatment with sulindac sulfide, a known COX inhibitor.
Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2
TLDR
Recent studies in humans indicate that therapy with specific COX-2 inhibitors might be an effective approach to colorectal cancer prevention and treatment.
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