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International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
Recommendations and guidelines on the evaluation and treatment of severe asthma in children and adults and coordinated research efforts for improved phenotyping will provide safe and effective biomarker-driven approaches to severe asthma therapy are provided. Expand
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsìveness, and the late asthmatic response
A single dose of monoclonal antibody to IL-5 decreased blood eosinophils for up to 16 weeks and sputum eosInophils at 4 weeks, which has considerable therapeutic potential for asthma and allergy, however, the findings question the role of eos inophils in mediating the late asthmatic response and causing airway hyper-responsiveness. Expand
Mucosal inflammation in asthma.
It is not possible to relate precisely the findings obtained by bronchoscopy to the clinical presentation and progression of asthma, but direct evidence obtained from allergen challenge leading to increased bronchial hyperresponsiveness during LAR, and direct evidence of inflammatory cells and their mediators in the airway mucosa and lumen after allergenic challenge argue for an active role of cells in bringing about inflammatory changes. Expand
Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines.
Human mast cells are identified as a source of IL-4,IL-5, IL-6, and TNF-alpha and add to the view that, along with T cells, mast cells may play an important role in initiating and maintaining the inflammatory response in asthma. Expand
Methods of sputum processing for cell counts, immunocytochemistry and in situ hybridisation
Two methods for processing the expectorate have evolved and there is conflicting data as to whether or not differential cell counts (DCCs) differ between the two methods. Expand
Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma.
The lack of effect of omalizumab on methacholine responsiveness suggests that IgE or eosinophils may not be causally linked to airway hyperresponsiveness to Methacholine in mild to moderate asthma. Expand
Defective epithelial barrier function in asthma.
The results show that the bronchial epithelial barrier in asthma is compromised, which may facilitate the passage of allergens and other agents into the airway tissue, leading to immune activation and may thus contribute to the end organ expression of asthma. Expand
Standardised methodology of sputum induction and processing
Research into the pathogenetic mechanisms and clinical monitoring of inammatory diseases of any system is complete only if it involves the study of both the underlying pathological features and theExpand
Sputum induction
Myofibroblasts and subepithelial fibrosis in bronchial asthma.
Researchers studied endobronchial biopsies from eight normal and seven asthmatic volunteers by immunohistochemistry and electron microscopy to determine the nature of the cell responsible for thickened bronchial epithelial basement membrane and found it to be myofibroblastic. Expand