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VPS35 mutations in Parkinson disease.
TLDR
This study implicates disruption of VPS35 and retromer-mediated trans-membrane protein sorting, rescue, and recycling in the neurodegenerative process leading to PD. Expand
The natural history of multiple system atrophy: a prospective European cohort study
TLDR
The final analysis of a prospective multicentre study by the European MSA Study Group provides new insights into the evolution of MSA based on a follow-up period that exceeds that of previous studies. Expand
Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
TLDR
It is shown that the pro-apoptotic protein Bax is highly expressed in the SNpc and that its ablation attenuates SNpc developmental neuronal apoptosis, and it is suggested that targeting Bax may provide protective benefit in the treatment of Parkinson's disease. Expand
Quantitative measurement of pain sensation in patients with Parkinson disease
TLDR
Endogenous pain in patients with Parkinson disease is accompanied by increased sensitivity to some painful stimuli, suggesting that basal ganglia abnormality also involves pain encoding. Expand
Presentation, diagnosis, and management of multiple system atrophy in Europe: Final analysis of the European multiple system atrophy registry
TLDR
This largest clinical series of MSA patients reported so far shows that the disease presents uniformly across Europe, and the observed differences in diagnostic and therapeutic management including lack of therapy for dysautonomia emphasize the need for future guidelines in these areas. Expand
Camptocormia (bent spine) in patients with Parkinson's disease—Characterization and possible pathogenesis of an unusual phenomenon
TLDR
Eight patients with presumed idiopathic Parkinson's disease who developed camptocormia are described for the first time, and this impressive abnormal posture emerged 4–14 years from disease onset, and in some patients stooped posture was the prominent symptom at diagnosis. Expand
The mystery of motor asymmetry in Parkinson's disease
TLDR
In this Personal View, data for unilaterality of symptoms at different disease stages is reviewed and several pathological, genetic, environmental, and toxic possibilities for explaining the mechanism of side predominance are discussed. Expand
Rasagiline Mesylate, a New Mao-B Inhibitor for the Treatment of Parkinson's Disease: A Double-Blind Study as Adjunctive Therapy to Levodopa
TLDR
It is demonstrated that rasagiline (up to 2 mg/day) has a good safety profile and a beneficial clinical effect in fluctuating patients with PD when given as an add-on to chronic levodopa therapy. Expand
Red flags for multiple system atrophy
TLDR
A combination of two out of six red flag categories as additional diagnostic criteria for probable MSA‐P is proposed and 76.5% of them would have been correctly diagnosed as probable Msa‐P 15.9 months earlier than with the Consensus criteria alone. Expand
Clinicogenetic study of mutations in LRRK2 exon 41 in Parkinson's disease patients from 18 countries
TLDR
Clinical phenotypes including psychosis, dementia, and MIBG ratios are also heterogeneous, similar to neuropathology, in PD associated with LRRK2 mutations, and I2020T mutation has a single‐founder effect in Japanese patients. Expand
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