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Paraquat Poisonings: Mechanisms of Lung Toxicity, Clinical Features, and Treatment
TLDR
The most pertinent and significant findings published in established scientific publications since the discovery of PQ are collected and described, focusing on the most recent developments related to PQ lung toxicity and their relevance to the treatment of human poisonings.
Metabolism and metabolomics of ketamine: a toxicological approach
TLDR
Knowing the metabolism and metabolomics of ketamine may provide further insights aiming to better characterize ketamine from a clinical and forensic perspective.
COVID-19 research: pandemic versus “paperdemic”, integrity, values and risks of the “speed science”
TLDR
This commentary reviews the concepts related to scientific integrity at a time when science faces important challenges related to the increase number of articles produced regarding research on coronavirus disease 2019 (COVID-19).
Comparative pharmacology and toxicology of tramadol and tapentadol
TLDR
Although more studies are needed to provide clear guidance on the opioid of choice, tapentadol shows some advantages, as it does not require CYP450 system activation and has minimal serotonergic effects, which leads to less side effects and lower abuse liability.
Metabolism of psilocybin and psilocin: clinical and forensic toxicological relevance
TLDR
This review aims to discuss metabolism of psilocybin and psilocin, by presenting all major and minor psychoactive metabolites, with clinical and forensic relevance in diagnosis.
Human and experimental toxicology of diquat poisoning: Toxicokinetics, mechanisms of toxicity, clinical features, and treatment
TLDR
The aim of this work was to review the most relevant human and experimental findings related to DQ, characterizing its chemistry, activity as herbicide, mechanisms of toxicity, consequences of poisoning, and potential therapeutic approaches taking into account previous experience in developing antidotes for paraquat, a more toxic bipyridinium herbicide.
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