R. Dinis-Oliveira

Publications185
h-index30
Citations3,796
Highly Influential Citations170
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Paraquat Poisonings: Mechanisms of Lung Toxicity, Clinical Features, and Treatment
Paraquat dichloride (methyl viologen; PQ) is an effective and widely used herbicide that has a proven safety record when appropriately applied to eliminate weeds. However, over the last decades,… Expand
Paraquat exposure as an etiological factor of Parkinson's disease.
Parkinson's disease (PD) is a multifactorial chronic progressive neurodegenerative disease influenced by age, and by genetic and environmental factors. The role of genetic predisposition in PD has… Expand
Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy.
P-glycoprotein (P-gp) is an ATP-dependent efflux pump encoded by the MDR1 gene in humans, known to mediate multidrug resistance of neoplastic cells to cancer therapy. For several decades, P-gp… Expand
Pesticides exposure as etiological factors of Parkinson's disease and other neurodegenerative diseases--a mechanistic approach.
The etiology of most neurodegenerative disorders is multifactorial and consists of an interaction between environmental factors and genetic predisposition. The role of pesticide exposure in… Expand
Metabolism and metabolomics of ketamine: a toxicological approach
ABSTRACT Ketamine is a phencyclidine derivative and a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptor for which glutamate is the full agonist. It produces a functional dissociation… Expand
P-glycoprotein induction: an antidotal pathway for paraquat-induced lung toxicity.
The widespread use of the nonselective contact herbicide paraquat (PQ) has been the cause of thousands of deaths from both accidental and voluntary ingestion. The main target organ for PQ toxicity is… Expand
Single high dose dexamethasone treatment decreases the pathological score and increases the survival rate of paraquat-intoxicated rats.
Dexamethasone (DEX), a synthetic corticosteroid, has been successfully used in clinical practice during paraquat (PQ) poisonings due to its anti-inflammatory activity, although, as recently observed,… Expand
Postmortem Analyses Unveil the Poor Efficacy of Decontamination, Anti-Inflammatory and Immunosuppressive Therapies in Paraquat Human Intoxications
Background Fatalities resulting from paraquat (PQ) self-poisonings represent a major burden of this herbicide. Specific therapeutic approaches have been followed to interrupt its toxic pathway,… Expand
Biological Evidence Management for DNA Analysis in Cases of Sexual Assault
Biological evidence with forensic interest may be found in several cases of assault, being particularly relevant if sexually related. Sexual assault cases are characterized by low rates of… Expand
COVID-19 research: pandemic versus “paperdemic”, integrity, values and risks of the “speed science”
Abstract Scientific integrity is a learned skill. When researchers and students learn integrity in laboratories or in the classroom, they are empowered to use similar principles in other aspects of… Expand
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