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P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite
BackgroundThe NLR family, pyrin domain-containing 3 (NLRP3) inflammasome plays a key role in intracerebral hemorrhage (ICH)-induced inflammatory injury, and the purinergic 2X7 receptor (P2X7R) is… Expand
Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-κB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant…
BackgroundIntracerebral hemorrhage (ICH) induces potently oxidative stress responses and inflammatory processes. Isoliquiritigenin (ILG) is a flavonoid with a chalcone structure and can activate… Expand
Blood–brain barrier disruption induced by hemoglobin in vivo: Involvement of up-regulation of nitric oxide synthase and peroxynitrite formation
- R. Ding, Yi-zhao Chen, Shuo Yang, Xin-qing Deng, Y. Tang
- Chemistry, Medicine
- Brain Research
- 7 July 2014
Accumulating evidence has demonstrated that up-regulation of nitric oxide synthase (NOS) and subsequent peroxynitrite (ONOO(-)) formation exert a devastating effect on the damage of BBB in multiple… Expand
Isolation and identification of lipopeptide antibiotics from Paenibacillus elgii B69 with inhibitory activity against methicillin-resistant Staphylococcus aureus
Two lipopeptide antibiotics, pelgipeptins C and D, were isolated from Paenibacillus elgii B69 strain. The molecular masses of the two compounds were both determined to be 1,086 Da. Mass-spectrometry,… Expand
Isolation and partial characterization of antibiotics produced by Paenibacillus elgii B69.
- X. Wu, Xiaobo Shen, R. Ding, Chao-dong Qian, Hai-Huan Fang, O. Li
- Biology, Medicine
- FEMS microbiology letters
- 1 September 2010
A newly isolated strain B69 with broad antimicrobial activity was identified as Paenibacillus elgii by 16S rRNA gene sequence analysis, along with physiological and biochemical characterization. Two… Expand
UWB Positioning System Based on Joint TOA and DOA Estimation: UWB Positioning System Based on Joint TOA and DOA Estimation
[Interaction between polymorphisms in NQO1(C609T) and XRCC1(G28152A) and their correlation with smoking on gastric cancer].
OBJECTIVE To investigate the relationship between polymorphism of NAD(P)H quinone oxidoreductase 1 (NQO1) and X-ray repair cross-complementing group1 (XRCC1) and their correlation with smoking on the… Expand
Facile and large-scale chemical synthesis of highly porous secondary submicron/micron-sized NiCo2O4 materials for high-performance aqueous hybrid AC-NiCo2O4 electrochemical capacitors
Highly porous nickel cobaltite (NiCo2O4) materials have been synthesized via a facile and scalable chemical synthesis route. The obtained NiCo2O4 material displays a typical secondary… Expand
Modification of cut-off values for HE4, CA125 and the ROMA algorithm for early-stage epithelial ovarian cancer detection: Results from 1021 cases in South China.
OBJECTIVES The purpose of this study was to evaluate the performance of human epididymis protein 4 (HE4) and the Risk of Ovarian Malignancy Algorithm (ROMA) in early stage epithelial ovarian cancer… Expand
Long noncoding RNA MRAK009713 is a novel regulator of neuropathic pain in rats
Abstract Long noncoding RNAs have been implicated in neuropathy. Here, we identify and validate a long noncoding RNA, MRAK009713, as the primary regulator of neuropathic pain in chronic constriction… Expand