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IL‐13 production by allergen‐stimulated T cells is increased in allergic disease and associated with IL‐5 but not IFN‐γ expression
TLDR
It is concluded that allergen‐specific T’cells from atopic subjects secrete elevated quantities of IL‐13 compared with non‐atopic controls, in the context of a Th2‐type pattern of cytokine production.
Secretion of the eosinophil‐active cytokines interleukin‐5, granulocyte/macrophage colonystimulating factor and interleukin‐3 by bronchoalveolar lavage CD4+ and CD8+ T cell lines in atopics
TLDR
Data are consistent with the hypothesis that activated T lymphocytes from asthmatics, particularly of the CD4+ subset, are predisposed to release elevated quantities of cytokines relevant to the accumulation and activation of eosinophils.
Allergen-induced proliferation and interleukin-5 production by bronchoalveolar lavage and blood T cells after segmental allergen challenge.
TLDR
Allergen-specific T cells can be detected in the bronchial lumen after allergen challenge and that allerden-induced proliferation and IL-5 production by these cells correlates with local eosinophil influx, consistent with the hypothesis that local differentiation or priming of these cells within the Bronchial mucosal environment results in upregulation of allergenic-induced IL- 5 secretion.
Engineering of a functional interleukin-5 monomer: a paradigm for redesigning helical bundle cytokines with therapeutic potential in allergy and asthma
TLDR
No differences in signal transduction pathways utilized by mono5 and IL-5 are demonstrated, as determined by western blot analysis of early tyrosine phosphorylation events, Jak2 activation, and mitogen-activated protein kinase activation.
Creation of a biologically active interleukin-5 monomer
TLDR
These studies demonstrate that all of the structural features necessary for IL-5 to function are contained within a single helical bundle.
IL‐5 production by allergen‐stimulated T cells following grass pollen immunotherapy for seasonal allergic rhinitis
TLDR
No significant reduction was observed in IL‐5 production when immunotherapy treated patients were compared with untreated rhinitic controls, suggesting that local immunodulation of T cell responses may play a role in this form of treatment.
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