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Postmarketing surveillance of zopiclone in insomnia: analysis of 20,513 cases.
The subjective response to the prescription drug zopiclone, an hypnotic agent belonging to the cyclopyrrolone family, was assessed under the usual conditions of prescription of an hypnotic in general… Expand
Importance of catecholamine release for the functional action of intrastriatal implants of adrenal medullary cells: Pharmacological analysis and in vivo electrochemistry
- R. Decombe, J. Rivot, D. Aunis, N. Abrous, M. Peschanski, J. Herman
- Medicine, Chemistry
- Experimental Neurology
- 1 February 1990
The results suggest that adrenal grafts can, under suitable conditions, influence the functioning of the host nervous system and suggest that the functional effects of such intrastriatal grafts of chromaffin cells, reported in previous studies, cannot be explained by the secretion from the grafted cells of catecholamines into the denervated striatum. Expand
Alteration of aminergic neurotransmitter release after two consecutive transient global ischaemias: an in vivo microdialysis study in rat.
- R. Decombe, D. Bentué‐Ferrer, H. Allain, J. J. van den Driessche
- Neurological research
- 1 June 1993
Data on the neuroamine changes induced by the second ischaemia could be used to assess the delay in aminergic neurotransmission subsequent to the primary injury, and could be explained by delayed impairment of release mechanisms, rather than by exhaustion of the releasable pools of these neurotransmitters one day after the first ischaemic period. Expand
Progress in Understanding the Pathophysiology of Cerebral Ischemia: The Almitrine‐Raubasine Approach
- D. Bentué‐Ferrer, R. Decombe, J. Reymann, C. Schatz, H. Allain
- Clinical neuropharmacology
Almitrine‐raubasine pharmacological studies indicate that this drug has several beneficial effects on cerebral ischemic processes, and potentially antiischemic drugs are used as an example. Expand
[Memory deficit in Parkinson's disease. Precocious aging of recall processes].
A specific pattern of memory impairment can be described in parkinsonism, which would suggest and support the theory that different pathogenic mechanisms are involved in ageing and in park Parkinsonian patients. Expand
Mechanistic Basis for the Development of Anti-Ischemic Drugs
The pharmacology of cerebral ischemia features 100 molecules and 20 potentially interesting mechanisms for preventing the tissue damage induced by anoxia-ischemia. The intricacy and complexity of the
Temporal profile of aminergic neurotransmitter release in striatal dialysates in rats with post-ischemic seizures
- D. Bentué‐Ferrer, É. Bellissant, R. Decombe, H. Allain
- Psychology, Medicine
- Experimental Brain Research
The temporal profiles of aminergic neurotransmitter levels and of their acid metabolites after transient global cerebral ischemia in awake rats with and without subsequent seizures were compared… Expand
Effect of brain microdialysis on aminergic transmitter levels in repeated cerebral global transient ischemia in rat
- S. Thaminy, É. Bellissant, M. Maginn, R. Decombe, H. Allain, D. Bentué‐Ferrer
- Journal of Neuroscience Methods
- 1 December 1996
The findings presented here indicate that combined with ischemia, probe reinsertion modifies the level of neurotransmitter release. Expand
Choosing a target for cognitive enhancers.
It is concluded that a better definition of the direct targets of cognitive enhancers can guarantee cost and time savings for the industry and produce a therapeutically effective agent. Expand