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Analgesie drugs in breast milk and plasma *
The disposition of salicylic acid, phenacetin, caffeine, and codeine, and two metabolites, acetaminophen and morphine, was studied in breast milk and plasma of two lactating mothers after single oralExpand
Lipid-soluble inhibitors of dihydrofolate reductase. I. Kinetics, tissue distribution, and extent of metabolism of pyrimethamine, metoprine, and etoprine in the rat, dog, and man.
Physicochemical properties, kinetics, and metabolism of a series of lipid-soluble 2,4-diamino-5-phenylpyrimidine folate antagonists, and pharmacokinetic studies in the mouse, rat, dog, and man indicate that metoprine has the longest plasma half-life in all four species. Expand
Effect of 3-methylcholanthrene pretreatment on the bioavailability of phenacetin in the rat.
It was concluded that the 7-fold reduction in the bioavailability of phenacetin observed in 3-MC treated rats was caused by a marked increase in the metabolism of Phenacetin during its first pass through the liver. Expand
High-performance liquid chromatographic analysis of doxacurium, a new long-acting neuromuscular blocker.
A rapid and sensitive high-performance liquid chromatographic procedure was developed for the analysis of the new, long-acting neuromuscular blocker doxacurium in the plasma and urine of dog and manExpand
Elimination of antipyrine from saliva as a measure of metabolism in man
The results show that the elimination rate of antipyrine from saliva is a useful index of drug metabolism in animals and man. Expand
Quantitative thin-layer chromatography of pyrimethamine and related diaminopyrimidines in body fluids and tissues.
Several 2,4-diaminopyrimidines which inhibit the enzyme dihydrofolate reductase are quantitated following extraction and separation on silica gel thin-layer chromatographic plates with a scanning instrument for the measurement of as little as 10 ng/ml of these compounds in biological fluids. Expand
Effect of Aroclor 1254, phenobarbital, and polycyclic aromatic hydrocarbons on the plasma clearance of caffeine in the rat
The above studies indicate that the plasma clearance of caffeine is markedly increased in rats pretreated with phenobarbital, PCH, or Aroclor 1254 and suggest that the metabolism and pharmacology of caffeine may be considerably altered in human subjects exposed to these substances. Expand
Triprolidine radioimmunoassay: disposition in animals and humans.
A comparison of triprolidine pharmacokinetic parameters in dogs, rabbits, rats, and humans revealed considerable similarity in elimination characteristics in these species. Expand