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Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival.
Tumor size predicts disease-specific survival in patients with primary disease who undergo complete gross resection and investigational protocols are indicated to reduce the rate of recurrence after resections and to improve the outcome for patients with GIST. Expand
NCCN Task Force report: update on the management of patients with gastrointestinal stromal tumors.
- G. Demetri, M. von Mehren, +10 authors J. Wayne
- Journal of the National Comprehensive Cancer…
- 1 April 2010
The standard of care for managing patients with gastrointestinal stromal tumors (GISTs) rapidly changed after the introduction of effective molecularly targeted therapies involving tyrosine kinase… Expand
Staging, Resectability, and Outcome in 225 Patients With Hilar Cholangiocarcinoma
By taking full account of local tumor extent, the proposed staging system for hilar cholangiocarcinoma accurately predicts resectability, the likelihood of metastatic disease, and survival. Expand
Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial
Adjuvant imatinib therapy is safe and seems to improve recurrence-free survival compared with placebo after the resection of primary gastrointestinal stromal tumour. Expand
Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery (ISGLS).
A definition and grading of severity of posthepatectomy liver failure is proposed, which can be used in future studies to allow objective and accurate comparisons of operative interventions in the field of hepatic surgery. Expand
Improvement in Perioperative Outcome After Hepatic Resection: Analysis of 1,803 Consecutive Cases Over the Past Decade
The number of hepatic segments resected and operative blood loss were the only independent predictors of both perioperative morbidity and mortality, and reductions in both are largely responsible for the decrease in peri operative mortality, which has occurred despite an increase in concomitant major procedures. Expand
Intrahepatic Cholangiocarcinoma: Rising Frequency, Improved Survival, and Determinants of Outcome After Resection
At Memorial Sloan-Kettering Cancer Center, intrahepatic cholangiocarcinoma incidence has increased dramatically in the last 16 years and the recent increase in survival seems largely because of improved nonoperative therapy for unresectable disease. Expand
Bile leakage after hepatobiliary and pancreatic surgery: a definition and grading of severity by the International Study Group of Liver Surgery.
A uniform definition and severity grading of bile leakage is proposed to enable a standardized comparison of the results of different clinical trials and may facilitate an objective evaluation of diagnostic and therapeutic modalities in the field of hepatobiliary and pancreatic operative therapy. Expand
Acquired Resistance to Imatinib in Gastrointestinal Stromal Tumor Occurs Through Secondary Gene Mutation
- C. Antonescu, P. Besmer, +10 authors R. DeMatteo
- Biology, Medicine
- Clinical Cancer Research
- 1 June 2005
That acquired resistance to imatinib in GIST commonly occurs via secondary gene mutation in the KIT kinase domain has implications for strategies to delay or preventImatinib resistance and to employ newer targeted therapies. Expand
Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits
It is demonstrated that antibiotic treatment of mice notably downregulates intestinal expression of RegIIIγ, a secreted C-type lectin that kills Gram-positive bacteria, including VRE, providing a potential therapeutic approach to reduce colonization and infection by antibiotic-resistant microbes. Expand