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The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.
Cell proliferation requires nutrients, energy, and biosynthetic activity to duplicate all macromolecular components during each passage through the cell cycle. It is therefore not surprising thatExpand
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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
Mammalian cells fuel their growth and proliferation through the catabolism of two main substrates: glucose and glutamine. Most of the remaining metabolites taken up by proliferating cells are notExpand
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Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
Tumor cell proliferation requires rapid synthesis of macromolecules including lipids, proteins, and nucleotides. Many tumor cells exhibit rapid glucose consumption, with most of the glucose-derivedExpand
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High Frequency Retrotransposition in Cultured Mammalian Cells
We previously isolated two human L1 elements (L1.2 and LRE2) as the progenitors of disease-producing insertions. Here, we show these elements can actively retrotranspose in cultured mammalian cells.Expand
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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functionalExpand
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The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche.
Bone marrow transplantation is the primary therapy for numerous hematopoietic disorders. The efficiency of bone marrow transplantation depends on the function of long-term hematopoietic stem cellsExpand
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Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation.
Dendritic cells (DCs) are key regulators of innate and acquired immunity. The maturation of DCs is directed by signal transduction events downstream of toll-like receptors (TLRs) and other patternExpand
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Brick by brick: metabolism and tumor cell growth.
Tumor cells display increased metabolic autonomy in comparison to non-transformed cells, taking up nutrients and metabolizing them in pathways that support growth and proliferation. Classical work inExpand
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Fundamentals of cancer metabolism
Researchers provide a conceptual framework to understand current knowledge of the fundamentals of cancer metabolism. Tumors reprogram pathways of nutrient acquisition and metabolism to meet theExpand
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Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer
Several decades of research have sought to characterize tumor cell metabolism in the hope that tumor-specific activities can be exploited to treat cancer. Having originated from Warburg's seminalExpand
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