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Spontaneous feline mammary carcinoma is a model of HER2 overexpressing poor prognosis human breast cancer.
Companion animal spontaneous tumors are suitable models for human cancer, primarily because both animal population and the tumors are genetically heterogeneous. Feline mammary carcinoma (FMC) is a… Expand
Tumour grading and the one-year post-surgical prognosis in feline mammary carcinomas.
- M. Castagnaro, C. Casalone, E. Bozzetta, R. De Maria, B. Biolatti, M. Caramelli
- Biology, Medicine
- Journal of comparative pathology
- 1 October 1998
To investigate whether the degree of differentiation in feline mammary carcinoma (FMC) can indicate the post-surgical survival time (PST), tumours were surgically resected from 55 cats and… Expand
Ki-67 index as indicator of the post-surgical prognosis in feline mammary carcinomas.
Forty-eight feline mammary carcinomas (FMC) were resected surgically from 48 cats to determine whether the Ki-67 index (Ki-67I) would provide an indication of the post-surgical survival time (PST).… Expand
Targeting immune response with therapeutic vaccines in premalignant lesions and cervical cancer: hope or reality from clinical studies
ABSTRACT Human papillomavirus (HPV) is widely known as a cause of cervical cancer (CC) and cervical intraepithelial neoplasia (CIN). HPVs related to cancer express two main oncogenes, i.e. E6 and E7,… Expand
Progesterone receptor gene expression in the accessory sex glands of veal calves
This study investigated progesterone receptor (PR) cDNA expression in the testes, prostate and bulbourethral glands of prepubertal calves treated experimentally with high and low doses of… Expand
Activation of AKT in feline mammary carcinoma: a new prognostic factor for feline mammary tumours.
The PI3K/AKT/PTEN pathway is involved in the pathogenesis of several human cancers. This study investigated the biological and prognostic value of PI3K/AKT/PTEN pathway dysregulation in feline… Expand
PDGFs and PDGFRs in canine osteosarcoma: new targets for innovative therapeutic strategies in comparative oncology.
Platelet derived growth factor receptor (PDGFR)α and PDGFRβ are tyrosine kinase receptors that are overexpressed in 70-80% of human osteosarcomas (OSAs) and may be suitable therapeutic targets for… Expand
CSPG4-Specific Immunity and Survival Prolongation in Dogs with Oral Malignant Melanoma Immunized with Human CSPG4 DNA
Purpose: Due to the many similarities with its human counterpart, canine malignant melanoma (cMM) is a valuable model in which to assess the efficacy of novel therapeutic strategies. The model is… Expand
Inter-laboratory comparison of a yeast bioassay for the determination of estrogenic activity in biological samples.
An inter-laboratory exercise was performed with a yeast estrogen bioassay, based on the expression of yeast enhanced green fluorescent protein (yEGFP), for the determination of estrogenic activity in… Expand
β-Galactosidase deficiency in a Korat cat: a new form of feline GM1-gangliosidosis
- R. De Maria, S. Divari, +4 authors M. Castagnaro
- Biology, Medicine
- Acta Neuropathologica
- 1 September 1998
Abstract A 7-month-old Korat cat was referred for a slowly progressive neurological disease. Circulating monocytes and lymphocytes showed the presence of single or multiple empty vacuoles and blood… Expand