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Clinical Pharmacokinetics of Metformin
The effect of structural variants of OCTs and other cation transporters on the pharmacokinetics of metformin appears small and the subsequent effects on clinical response are limited, however, intersubject differences in the levels of expression of OCT1 and OCT3 in the liver are very large and may contribute more to the variations in the hepatic uptake and clinical effect of metforms.
Association of interruptions with an increased risk and severity of medication administration errors.
Among nurses at 2 hospitals, the occurrence and frequency of interruptions were significantly associated with the incidence of procedural failures and clinical errors and was associated with higher procedural failure rates.
The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings
The result is that paracetamol does not suppress the severe inflammation of rheumatoid arthritis and acute gout but does inhibit the lesser inflammation resulting from extraction of teeth and is also active in a variety of inflammatory tests in experimental animals.
Effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects.
St John's wort significantly induced the apparent clearance of both S-warfarin and R-warFarin, which in turn resulted in a significant reduction in the pharmacological effect of rac-war Farin, and Coadministration of warfarin with ginseng did not affect the pharmacokinetics or pharmacodynamics of either S- Warfarin or R-Warfarin.
Effects of Two Commercial Electronic Prescribing Systems on Prescribing Error Rates in Hospital In-Patients: A Before and After Study
In a before-and-after study, Johanna Westbrook and colleagues evaluate the change in prescribing error rates after the introduction of two commercial electronic prescribing systems in two Australian
Non steroidal anti-inflammatory drugs.
  • R. Day
  • Medicine
    Australian family physician
  • 1987
Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects.
Ginkgo and ginger at recommended doses do not significantly affect clotting status, the pharmacokinetics or pharmacodynamics of warfarin in healthy subjects and these herbs did not affect CYP2C9 activity.
Clinical Pharmacokinetics and Pharmacodynamics of Allopurinol and Oxypurinol
Measurement of plasma concentrations of oxypurinol in selected patients, particularly those with renal impairment, may help to decrease the risk of toxicity and improve the hypouricaemic response.
Efficacy and safety of paracetamol for spinal pain and osteoarthritis: systematic review and meta-analysis of randomised placebo controlled trials
P acetamol is ineffective in the treatment of low back pain and provides minimal short term benefit for people with osteoarthritis, and these results support the reconsideration of recommendations to use paracetamol for patients with low backPain and osteOarthritis of the hip or knee in clinical practice guidelines.