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Poly(ADP-ribose) Polymerase-1 Inhibition Prevents Eosinophil Recruitment by Modulating Th2 Cytokines in a Murine Model of Allergic Airway Inflammation: A Potential Specific Effect on IL-51
We recently used a murine model of allergic airway inflammation to show that poly(ADP-ribose) polymerase-1 (PARP-1) plays an important role in the pathogenesis of asthma-related lung inflammation. InExpand
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Poly(ADP-Ribose) Polymerase Inhibition Reduces Atherosclerotic Plaque Size and Promotes Factors of Plaque Stability in Apolipoprotein E–Deficient Mice: Effects on Macrophage Recruitment, Nuclear
Background— Poly(ADP-ribose) polymerase (PARP) was suggested to play a role in endothelial dysfunction that is associated with a number of cardiovascular diseases. We hypothesized that PARP may playExpand
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Reciprocal regulation of iNOS and PARP-1 during allergen-induced eosinophilia
Inducible nitric oxide synthase (iNOS) inhibition was recently shown to exert no effect on allergen challenge in human asthma, raising serious concerns about the role of the protein in the disease.Expand
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Induction of apoptosis‐like cell death and clearance of stress‐induced intracellular protein aggregates: dual roles for Ustilago maydis metacaspase Mca1
Metacaspases primarily associate with induction and execution of programmed cell death in protozoa, fungi and plants. In the recent past, several studies have also demonstrated cellular functions ofExpand
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Effect of Ethyl Acetate Extract and Purified Compounds of Alpinia galanga (L.) on Immune Response of a Polyphagous Lepidopteran Pest, Spodoptera litura (Fabricius)
Plant derived products provide defense to plants against herbivore insects by acting as antifeedant, growth regulators, toxins and modulate the activity of various enzyme. Additionally botanicals canExpand
Biology-oriented diverted synthesis of glutamate analogs
21 days and consequently, DON caused obvious damages to piglets of toxic group. However, clinic parameters, like intestinal morphology, the amino acids concentrations in the serum, jejunum and ileumExpand