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The orofacial formalin test in rats: effects of different formalin concentrations
&NA; In this study of the orofacial formalin test in rats, the effects of different formalin concentrations (0.2%, 0.5%, 1.5%, 2.5%, 5% and 10%) on the behavioural nociceptive response (face rubbing)Expand
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The orofacial formalin test
The subcutaneous injection of formalin into the rat upper lip generates behavioral responses that last several minutes. The time course of the response is similar to what is observed followingExpand
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The orofacial formalin test in the mouse: a behavioral model for studying physiology and modulation of trigeminal nociception.
UNLABELLED The aim of the current study was to adapt the orofacial formalin pain model previously developed in rats for use in mice and to characterize as fully as possible the behavioral changes inExpand
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Glycine Inhibitory Dysfunction Turns Touch into Pain through PKCgamma Interneurons
Dynamic mechanical allodynia is a widespread and intractable symptom of neuropathic pain for which there is a lack of effective therapy. During tactile allodynia, activation of the sensory fibersExpand
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Stimulation of craniofacial muscle afferents induces prolonged facilitatory effects in trigeminal nociceptive brain-stem neurones
&NA; Stimulation of small‐diameter afferents supplying deep tissues has been shown to increase the excitability of spinal cord neurones responding to cutaneous afferent inputs. This facilitation hasExpand
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Organization of the efferent projections from the spinal cervical enlargement to the parabrachial area and periaqueductal graye. A PHA‐L study in the rat
The organization of efferent projections from the spinal cervical enlargement to the parabrachial (PB) area and the periaqueductal gray (PAG) was studied in the rat by using microinjections ofExpand
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Application of the formalin test to the study of orofacial pain in the rat
A modification of the formalin test for assessing pain and analgesia in the orofacial region of the rat is described. A formalin solution (5%) was subcutaneously injected into the upper lip, then theExpand
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The orofacial capsaicin test in rats: effects of different capsaicin concentrations and morphine
&NA; The aim of this study was to develop a rat model of capsaicin‐induced pain in the orofacial region. We examined the effects of subcutaneous injection of different doses of capsaicin (0.25, 0.4,Expand
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Evidence for a peripheral origin of the tonic nociceptive response to subcutaneous formalin
&NA; The orofacial formalin test in the rat is a valid and reliable model of nociception and is sensitive to various classes of analgesic drugs. The noxious stimulus consists in an injection ofExpand
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Properties of nociceptive and non-nociceptive neurons in trigeminal subnucleus oralis of the rat
Recent studies have provided evidence suggesting the involvement of rostral components of the V brainstem complex such as trigeminal (V) subnucleus oralis in orofacial pain mechanisms. Since thereExpand
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