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Structural, neurochemical and behavioural consequences of neonatal blockade of NMDA receptor through chronic treatment with CGP 39551 or MK-801.
The results suggest that blockade of NMDA receptors during the critical period of brain maturation may result in permanent alteration of neural circuits and long-lasting alteration of motor behaviour. Expand
Chronic neonatal blockade of n-methyl-D-aspartate receptor by CGP 39551 increases dopaminergic function in adult rat
The study demonstrates that chronic blockade of N-methyl-D-aspartate receptor during the critical period of brain maturation results in long-lasting dopaminergic functional changes. Expand
Neurotoxicity of Polyamines and Pharmacological Neuroprotection in Cultures of Rat Cerebellar Granule Cells
It is demonstrated that polyamines are toxic to granule cells in culture and that this toxicity is mediated through the NMDA receptor by interaction of exogenously added polyamines with endogenous glutamate released by neurons in the medium. Expand
Differential enhancement of behavioral sensitivity to apomorphine following chronic treatment of rats with (-)-sulpiride and haloperidol.
Rat exploratory activity as well as apomorphine-induced hypermotility and stereotyped behavior were assayed following acute or chronic administration of sulpiride stereoisomers and haloperidol and the results are discussed in terms of differential dopamine receptor supersensitivity arising from prolonged administration of butyrophenone and substituted benzamide. Expand
Olanzapine counteracts stress-induced anxiety-like behavior in rats
Atypical antipsychotics, such as olanzapine, have been reported to display anxiolytic properties as shown in several preclinical and clinical studies. Furthermore, several experimental evidences haveExpand
Chronic treatment with MK-801 decreases D2 dopamine receptor function in rat striatum
The data suggest that the changes in DAergic function following repeated administrations with MK-801 could be suggestive of potential therapeutic uses of negative allosteric drugs in some DA related dysfunctions. Expand
Long-lasting effects of chronic neonatal blockade of N-methyl-d-aspartate receptor through the competitive antagonist CGP 39551 in rats
It is concluded that chronic blockade of the N-methyl-D-aspartate receptor during neonatal brain maturation results in long-lasting alteration of locomotor activity which appears related to functional changes of the dopamine receptors as well as to an altered balance between various excitatory and inhibitory neurotransmitter and neuromodulatory systems. Expand
Determination of Olanzapine in rat brain using liquid chromatography with coulometric detection and a rapid solid-phase extraction procedure.
This method proved to be suitable for the analysis of Olanzapine in rat brain tissues and for the study of distribution and pharmacokinetics of Olanzaapine after a single treatment with the antipsychotic drug. Expand
Nafadotride administration increases D1 and D1/D2 dopamine receptor mediated behaviors
The results suggest that the blockade of D3 receptors by nafadotride could have favored D1/D2 dopamine receptor-mediated behaviors by potentiating D1 receptor function. Expand
Water T-maze, an improved method to assess spatial working memory in rats: Pharmacological validation
The water escape T-maze might be a valid method to assess spatial working memory, sensitive to pharmacological manipulations, according to evidence showing a functional interaction between ionotropic and metabotropic glutamatergic receptors. Expand