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Evaluation and Improvement of Real-Time PCR Assays Targeting lytA, ply, and psaA Genes for Detection of Pneumococcal DNA
Three novel real-time PCR assays designed for the detection of specific sequence regions of the lytA, ply, and psaA genes were developed and should be considered the assays of choice for the Detection of pneumococcal DNA, particularly when upper respiratory P-LVS might be present in the clinical specimen.
Identification and Characterization of a Novel Family of Pneumococcal Proteins That Are Protective against Sepsis
Recombinant PhtA, PhtB, and PhtD elicited protection against certain pneumococcal capsular types in a mouse model of systemic disease and may serve as effective vaccines against the most prevalent pneumococCal serotypes.
The fundamental link between pneumococcal carriage and disease
- B. Simell, K. Auranen, H. Käyhty, D. Goldblatt, R. Dagan, K. O'Brien
- Medicine, BiologyExpert review of vaccines
- 1 July 2012
The use of vaccine effect on carriage as part of the vaccine licensure and post-vaccine introduction evaluation could facilitate and expand the licensure of new, life-saving pneumococcal vaccines and enable a comprehensive estimate of population effects after vaccine introduction.
Identification of infants unlikely to have serious bacterial infection although hospitalized for suspected sepsis.
Serological criteria for evaluation and licensure of new pneumococcal conjugate vaccine formulations for use in infants.
Otitis media and its consequences: beyond the earache.
Comparison of Human Metapneumovirus, Respiratory Syncytial Virus and Influenza A Virus Lower Respiratory Tract Infections in Hospitalized Young Children
- D. Wolf, D. Greenberg, R. Dagan
- Medicine, BiologyThe Pediatric infectious disease journal
- 1 April 2006
The clinical pattern of HMPV more closely resembles that of RSV than that of influenza A LRI, yet the differences in age, radiographic findings and clinical diagnosis suggest that H MPV pathogenesis may differ from that ofRSV.
Reduction of nasopharyngeal carriage of Streptococcus pneumoniae after administration of a 9-valent pneumococcal conjugate vaccine to toddlers attending day care centers.
A double-blind, randomized study involving 264 toddlers attending day care centers was conducted to document the effect of a 9-valent pneumococcal conjugate vaccine on the carriage rate of pneumococci, finding protection against carriage of S. pneumoniae serotypes 6B, 9V, 14, 19F, and 23F.
Association of serotype with risk of death due to pneumococcal pneumonia: a meta-analysis.
- D. Weinberger, Z. Harboe, M. Lipsitch
- Medicine, BiologyClinical infectious diseases : an official…
- 15 September 2010
A systematic review and meta-analysis of serotype-specific disease outcomes for patients with pneumonia and meningitis suggests that IPD outcome, like other epidemiologic measures, is a stable serotypes-associated property.
Nasopharyngeal carriage of Streptococcus pneumoniae by adults and children in community and family settings.
- G. Regev-Yochay, M. Raz, E. Rubinstein
- MedicineClinical infectious diseases : an official…
- 1 March 2004
Young age, day care center attendance, having young siblings, and no antibiotic use during the month before screening were associated with the high carriage rate among children, whereas the only risk factor associated with carriage among adults was the presence of a respiratory infection on the screening day.