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CYP2D6 and CYP2C19 activity in a large population of Dutch healthy volunteers: indications for oral contraceptive-related gender differences
TLDR
In EM females compared to EM males, CYP2D6 activity is increased and CyP2C19 activity is reduced, and this reduction is substantial and most pronounced in the age range from 18 to 40 years.
Transdermal drug delivery: efficacy and potential applications of the penetration enhancer Azone.
TLDR
It is concluded that the compound Azone is safe for human use, and of value in enhancing the cutaneous absorption of many types of drugs.
Isolation of acidic, neutral, and basic drugs from whole blood using a single mixed-mode solid-phase extraction column.
TLDR
A solid-phase extraction procedure was developed for the isolation of acidic, neutral, and basic drugs from whole blood and the drugs with pKa's close to the pH of the extraction system appeared in both fractions.
Solid-phase extraction procedures in systematic toxicological analysis.
Glucuronidation of labetalol at the two hydroxy positions by bovine liver microsomes. Isolation, purification, and structure elucidation of the glucuronides of labetalol.
TLDR
Structural elucidation of the various glucuronides was done by nuclear magnetic resonance, ultraviolet spectroscopy, and mass spectrometry and confirmed by performing reference incubations using radiolabeled UDP-glucuronic acid.
Recent innovations in the use of charged cyclodextrins in capillary electrophoresis for chiral separations in pharmaceutical analysis
TLDR
A review is presented on the use of charged cyclodextrins (CDs) as chiral selectors in capillary electrophoresis (CE) for the separation of analytes in pharmaceutical analysis and of theoretical models developed for a better prediction of the enantiomeric resolution and of the separation mechanism.
An enzymic digestion and solid-phase extraction procedure for the screening for acidic, neutral, and basic drugs in liver using gas chromatography for analysis.
TLDR
A workup and extraction scheme based on a recently developed procedure for the screening of biological fluids was developed that can be used for the screenings of acidic, neutral, and basic drugs in liver.
The prevalence of CYP2D6 and CYP2C19 genotypes in a population of healthy Dutch volunteers
TLDR
The frequencies of CYP1D6 and CYP2C19 allelic variants were in accordance with other European populations, and a gene–dose effect was found for CYP 2C19.
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