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Regulation of P2X4 receptors by lysosomal targeting, glycan protection and exocytosis
The P2X4 receptor has a widespread distribution in the central nervous system and the periphery, and plays an important role in the function of immune cells and the vascular system. Its upregulationExpand
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Evidence for functional P 2 X 4 / P 2 X 7 heteromeric receptors
The cytolytic ionotropic ATP receptor, P2X7, has several important roles in immune cell regulation such as cytokine release, apoptosis and microbial killing. Although P2X7 receptors are frequentlyExpand
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The trafficking and targeting of P2X receptors
The functional expression of P2X receptors at the plasma membrane is dependent on their trafficking along secretory and endocytic pathways. There are seven P2X receptor subunits, and these differ inExpand
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Sigma1 receptors inhibit store-operated Ca2+ entry by attenuating coupling of STIM1 to Orai1
Sigma1 receptors inhibit store-operated Ca2+ entry and reduce the Ca2+ content of the intracellular stores. These effects are regulated by Sigma1 receptor ligands. A ligand-dependent interactionExpand
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A role for P2X4 receptors in lysosome function
Murrell-Lagnado provides insight into new research revealing the physiological role of lysosomal P2X4 channels.
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Sigma1 receptors inhibit store-operated Ca2+ entry by attenuating coupling of STIM1 to Orai1
Atomic force microscopy (AFM) analyses of interactions between the sigma-1 receptor (σ1R), STIM1 and Orai1 isolated from the plasma membrane. Data include: 1. AFM images of Orai1 isolated with σ1RExpand
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P2X4 and lysosome fusion.
Similar to other members of the P2X receptor family, the P2X4 receptor at the plasma membrane forms a highly Ca2+ permeable, non-selective cation channel that is activated by extracellular ATP. Yet,Expand
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Regulation of P2X Purinergic Receptor Signaling by Cholesterol.
P2X receptors are cation-selective channels that are activated by the binding of extracellular ATP. They have a high permeability to Ca2+, Na+, and K+ and are expressed widely throughout the nervous,Expand
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The Sigma1 Receptor Competes with STIM1 to Bind Orai1 to Regulate Store Operated Calcium Entry (SOCE)
The Sigma1 receptor is an ER chaperone protein targeted to mitochondrial associated ER membrane regions (MAMs). An increase in its expression has been observed in a variety of cancer cells and itExpand
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Effects of piperine, the pungent ingredient of black pepper, at the human vanilloid receptor (TRPV1)
Piperine is a pungent alkaloid found in many species of the genus Piper. The structure of this molecule somewhat resembles that of capsaicin, another culinary alkaloid, and the best known of theExpand
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