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Identification and Subcellular Localization of the Subunits of L-type Calcium Channels and Adenylyl Cyclase in Cardiac Myocytes*
The properties of cardiac L-type channels have been well characterized electrophysiologically, and many such studies have demonstrated that the channels are regulated by a cAMP-dependent pathway.Expand
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Antidiabetic sulfonylureas control action potential properties in heart cells via high affinity receptors that are linked to ATP-dependent K+ channels.
Both avian and mammalian heart cells have high affinity receptors for antidiabetic sulfonylureas. The biochemical identification of these receptors has been carried out with [3H]glibenclamide. The KdExpand
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Adenosine A1 and A2 receptors of the substantia gelatinosa are located predominantly on intrinsic neurons: an autoradiography study.
Tissue autoradiography was used to examine the distribution of A1 and A2 adenosine receptors in the rat spinal cord. The distribution of binding sites for the A1 selective agonist,Expand
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Expression of PKA inhibitor (PKI) gene abolishes cAMP-mediated protection to endothelial barrier dysfunction.
We investigated the hypothesis that cAMP-dependent protein kinase (PKA) protects against endothelial barrier dysfunction in response to proinflammatory mediators. An E1-, E3-, replication-deficientExpand
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Adenosine analogs and sleep in rats.
The effects of N6-L-(phenylisopropyl)adenosine, cyclohexyladenosine and adenosine-5'-N-ethylcarboxamide on sleep were examined in rats. These effects consist of 1) increased slow-wave sleep2 from 6.6Expand
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Identification of A1 and A2 adenosine receptors in the rat spinal cord.
The adenosine receptors in membranes prepared from rat ventral and dorsal lumbar spinal cord were characterized by comparing the binding characteristics of [3H]5'-N-ethylcarboxamide adenosineExpand
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Analysis of beta receptor drug interactions in isolated rabbit atrium, aorta, stomach and trachea.
Several reports of in vivo experiments indicate that some compounds produce "selective" effects on the beta adrenergic receptors of different tissues. One explanation for selectivity is the existenceExpand
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Modulation of striatal dopaminergic function by local injection of 5'-N-ethylcarboxamide adenosine.
Rats rotated to the left when 5'-N-ethylcarboxamide adenosine (NECA) was injected into the left caudate nucleus and apomorphine was administered subcutaneously. The combination of NECA andExpand
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Modulation of cardiac cyclic AMP metabolism by adenosine receptor agonists and antagonists.
The mechanism(s) underlying adenosine receptor-mediated modulation of cardiac cAMP levels has been investigated using detergent-permeabilized embryonic chick ventricular myocytes. The beta-adrenergicExpand
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Calcium entry via L-type calcium channels acts as a negative regulator of adenylyl cyclase activity and cyclic AMP levels in cardiac myocytes.
It is well established that the inotropic effect of beta-adrenergic agonists is mediated by the stimulation of adenylyl cyclase activity and the subsequent phosphorylation of specific proteins byExpand
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