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Indirect comparisons of competing interventions.
OBJECTIVES To survey the frequency of use of indirect comparisons in systematic reviews and evaluate the methods used in their analysis and interpretation. Also to identify alternative statisticalExpand
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Trastuzumab containing regimens for early breast cancer.
BACKGROUND Approximately one-fifth of women who develop early breast cancer have HER2-positive tumours, which if untreated, have a worse prognosis than HER2-negative tumours. Trastuzumab is aExpand
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Use in routine clinical practice of two commercial blood tests for diagnosis of infection with Mycobacterium tuberculosis: a prospective study
BACKGROUND Two commercial blood assays for the diagnosis of latent tuberculosis infection--T-SPOT.TB and QuantiFERON-TB Gold--have been separately compared with the tuberculin skin test. Our aim wasExpand
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Antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving intensive care.
BACKGROUND Pneumonia is an important cause of mortality in intensive care units (ICUs). The incidence of pneumonia in ICU patients ranges between 7% and 40%, and the crude mortality fromExpand
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Effect of arterial revascularisation on survival: a systematic review of studies comparing bilateral and single internal mammary arteries
BACKGROUND Coronary artery bypass grafting (CABG) is the commonest major operation in most developed countries. A single internal mammary artery (IMA) graft has proven survival benefits, but theExpand
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Immunomodulators and immunosuppressants for relapsing-remitting multiple sclerosis: a network meta-analysis.
BACKGROUND Different therapeutic strategies are available for the treatment of people with relapsing-remitting multiple sclerosis (RRMS), including immunomodulators, immunosuppressants and biologics.Expand
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Assessment of methodological quality of primary studies by systematic reviews: results of the metaquality cross sectional study
Abstract Objectives To describe how the methodological quality of primary studies is assessed in systematic reviews and whether the quality assessment is taken into account in the interpretation ofExpand
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Performance of tests for latent tuberculosis in different groups of immunocompromised patients.
BACKGROUND Immunocompromised persons infected with Mycobacterium tuberculosis (MTB) have increased risk of tuberculosis (TB) reactivation, but their management is hampered by the occurrence ofExpand
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Immunomodulators and immunosuppressants for multiple sclerosis: a network meta-analysis.
BACKGROUND Different therapeutic strategies are available for treatment of multiple sclerosis (MS) including immunosuppressants, immunomodulators, and monoclonal antibodies. Their relativeExpand
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Preoperative chemotherapy plus trastuzumab, lapatinib, or both in human epidermal growth factor receptor 2-positive operable breast cancer: results of the randomized phase II CHER-LOB study.
PURPOSE This is a noncomparative, randomized, phase II trial of preoperative taxane-anthracycline in combination with trastuzumab, lapatinib, or combined trastuzumab plus lapatinib in patients withExpand
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