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Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond.
TLDR
Two new measures, one based on integrated sensitivity and specificity and the other on reclassification tables, are introduced that offer incremental information over the AUC and are proposed to be considered in addition to the A UC when assessing the performance of newer biomarkers. Expand
Prediction of coronary heart disease using risk factor categories.
TLDR
A simple coronary disease prediction algorithm was developed using categorical variables, which allows physicians to predict multivariate CHD risk in patients without overt CHD. Expand
General Cardiovascular Risk Profile for Use in Primary Care: The Framingham Heart Study
TLDR
A sex-specific multivariable risk factor algorithm can be conveniently used to assess general CVD risk and risk of individual CVD events (coronary, cerebrovascular, and peripheral arterial disease and heart failure) and can be used to quantify risk and to guide preventive care. Expand
Goodness-of-Fit-Techniques
"Overview, Ralph B. D'Agostino and Michael A. Stephens Graphical Analysis, Ralph B. D'Agostino Tests of Chi-Squared Type, David S. Moore Tests Based on EDF Statistics, Michael A. Stephens Tests BasedExpand
Impact of atrial fibrillation on the risk of death: the Framingham Heart Study.
TLDR
There was a significant AF-sex interaction: AF diminished the female advantage in survival and AF remained significantly associated with excess mortality, with about a doubling of mortality in both sexes in subjects free of valvular heart disease and preexisting cardiovascular disease. Expand
Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers.
TLDR
A prospective formulation for the NRI is proposed which offers immediate application to survival and competing risk data as well as allows for easy weighting with observed or perceived costs and is more objective and comparable across studies using the category-free version. Expand
Vitamin D Deficiency and Risk of Cardiovascular Disease
TLDR
Vitamin D deficiency is associated with incident cardiovascular disease and further clinical and experimental studies may be warranted to determine whether correction of vitamin D deficiency could contribute to the prevention of cardiovascular disease. Expand
2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.
TLDR
Harmon S. Jordan, ScD, Lev Nevo, MD, Janusz Wnek, PhD Jeffrey L. Anderson,MD, FACC, FAHA, Chair-Elect, Nancy M. Halperin, PhD. Expand
Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease
TLDR
Dementia developed in 111 subjects, including 83 given a diagnosis of Alzheimer's disease, over a median follow-up period of eight years, and plasma levels of folate and vitamins B12 and B6 increased. Expand
Independent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart Study.
TLDR
In addition to intrinsic cardiac causes such as valve disease and congestive heart failure, risk factors for cardiovascular disease also predispose to atrial fibrillation. Expand
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