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Human embryonic stem cell-derived mesenchymal stromal cells ameliorate collagen-induced arthritis by inducing host-derived indoleamine 2,3 dioxygenase
BackgroundThe immunosuppressive and anti-inflammatory properties of mesenchymal stromal cells (MSC) have prompted their therapeutic application in several autoimmune diseases, including rheumatoidExpand
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Detailed Characterization of Mesenchymal Stem/Stromal Cells from a Large Cohort of AML Patients Demonstrates a Definitive Link to Treatment Outcomes
Summary Bone marrow mesenchymal stem/stromal cells (BM-MSCs) are key components of the hematopoietic niche thought to have a direct role in leukemia pathogenesis. BM-MSCs from patients with acuteExpand
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Distribution of L1-retroposons on the giant sex chromosomes of Microtus cabrerae (Arvicolidae, Rodentia): functional and evolutionary implications
Long interspersed nuclear elements (L1 or LINE-1) are the most abundant and active retroposons in the mammalian genome. Traditionally, the bulk of L1 sequences have been explained by the ‘selfishExpand
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The Relative rDNA Content of a NOR Determines its Level of Expression and its Probability of Becoming Active. A Sequential Silver Staining and In-Situ Hybridization Study
Silver staining was used to estimate the expression of nucleolar organizing regions (NORs), and in-situ hybridization (ISH) with rDNA probes was used to estimate the relative content of rDNA in eachExpand
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XY females in Microtus cabrerae (Rodentia, Microtidae): a case of possibly Y-linked sex reversal.
Microtus cabrerae is a species with blocks of heterochromatin on both sex chromosomes. Polymorphism caused by extensive deletions affecting these heterochromatic segments exists in both X and YExpand
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A rapid, simple and reliable combined method for G-banding mammalian and human chromosomes.
A simple and reliable method for G-banding chromosomes from human and mammalian cells is described. This rapid method combines hot saline and trypsin treatments and yields high quality G-bands inExpand
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Fertile females of the mole Talpa occidentalis are phenotypic intersexes with ovotestes.
We investigated the origin of XX sex reversal in the insectivorous mole Talpa occidentalis. Cytogenetic, histological and hormonal studies indicate that all XX individuals analyzed from two differentExpand
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Multiple, polymorphic copies of SRY in both males and females of the vole Microtus cabrerae.
In mammals, sex determination is controlled by the Y-linked gene SRY. Although SRY is male-specific in most eutherian and marsupial species, with a single copy on the Y chromosome, several rodentExpand
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Heterogeneous heterochromatin and size variation in the sex chromosomes of Microtus cabrerae.
The sex chromosomes of Microtus cabrerae are characterized by large segments of constitutive heterochromatin in both the X and Y. Alkali treatment, enzymatic digestion (trypsin), and fluorochromeExpand
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X chromosome painting in Microtus: Origin and evolution of the giant sex chromosomes
Sex chromosomes in species of the genus Microtus present some characteristic features that make them a very interesting group to study sex chromosome composition and evolution. M. cabrerae and M.Expand
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