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Risk of lymphoproliferative disorders after bone marrow transplantation: a multi-institutional study.
It is concluded that factors associated with altered immunity and T-cell regulatory mechanisms are predictors of both early- and late-onset PTLD. Expand
Breast cancer following radiotherapy and chemotherapy among young women with Hodgkin disease.
Hormonal stimulation appears important for the development of radiation-induced breast cancer, as evidenced by the reduced risk associated with ovarian damage from alkylating agents or radiation. Expand
Risk factors for lymphoproliferative disorders after allogeneic hematopoietic cell transplantation.
These findings identify subgroups of patients who underwent allogeneic HCT at elevated risk of PTLDs for whom prospective monitoring of Epstein-Barr virus activation and early treatment intervention may be particularly beneficial. Expand
Lung cancer following chemotherapy and radiotherapy for Hodgkin's disease.
Past treatments with alkylating agents and radiation therapy for Hodgkin's disease were associated with an increased risk of lung cancer in a dose-dependent and additive fashion, but the precise risk estimates should be interpreted cautiously, given the possible residual and enhancing effects of tobacco. Expand
Second malignancies in prostate carcinoma patients after radiotherapy compared with surgery
In the treatment of prostate carcinoma, radiotherapy and surgery are common choices of comparable efficacy; thus a realistic comparison of the potential long term sequelae, such as the risk of secondExpand
Acute leukemia incidence and patient survival among children and adults in the United States, 2001-2007.
Assessment of AL incidence rates, IR ratios, and relative survival in the United States (2001-2007) shows distinct AL incidence and survival patterns based on the World Health Organization classification support biologic diversity that should facilitate etiologic discovery, prognostication, and treatment advances. Expand
Solid cancers after bone marrow transplantation.
The trend toward an increased risk over time after transplantation and the greater risk among younger patients indicate the need for life-long surveillance. Expand
Risk of leukemia after chemotherapy and radiation treatment for breast cancer.
Although leukemia occurs in few patients with breast cancer, significantly elevated risks were linked to treatments with regional radiation and alkylating agents, and melphalan is a more potent leukemogen than cyclophosphamide or radiotherapy. Expand
Risk of second malignant neoplasms among long-term survivors of testicular cancer.
Men with testicular cancer continue to be at significantly elevated risk of second malignant neoplasms for more than two decades following initial diagnosis, and patterns of excess second cancers suggest that many factors may be involved. Expand