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Identification and quantification of apo-lycopenals in fruits, vegetables, and human plasma.
Research has suggested that lycopene may be metabolized by eccentric cleavage, catalyzed by beta-carotene oxygenase 2, resulting in the generation of apo-lycopenals. Apo-6'-lycopenal andExpand
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Naturally Occurring Eccentric Cleavage Products of Provitamin A β-Carotene Function as Antagonists of Retinoic Acid Receptors*
Background: Dietary β-carotene can be cleaved centrally to vitamin A, an agonist of retinoic acid receptors, or eccentrically to yield β-apocarotenoids. Results: β-Apocarotenoids antagonize retinoicExpand
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Substrate Specificity of Purified Recombinant Human β-Carotene 15,15′-Oxygenase (BCO1)*
Background: The human enzyme β-carotene 15,15′-oxygenase (BCO1) produces vitamin A from carotenoids in food. Results: BCO1 catalyzes the oxidative cleavage of the 15–15′ double bond of major dietaryExpand
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Identification of Dihydroceramide Desaturase as a Direct in Vitro Target for Fenretinide*
The dihydroceramide desaturase (DES) enzyme is responsible for inserting the 4,5-trans-double bond to the sphingolipid backbone of dihydroceramide. We previously demonstrated that fenretinide (4-HPR)Expand
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Carotene and novel apocarotenoid concentrations in orange-fleshed Cucumis melo melons: determinations of β-carotene bioaccessibility and bioavailability.
Muskmelons, both cantaloupe (Cucumis melo Reticulatus Group) and orange-fleshed honeydew (C. melo Inodorus Group), a cross between orange-fleshed cantaloupe and green-fleshed honeydew, are excellentExpand
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The Human Enzyme That Converts Dietary Provitamin A Carotenoids to Vitamin A Is a Dioxygenase*
Background: The human enzyme β-carotene 15–15′-oxygenase (BCO1) has been thought to be a monooxygenase. Results: Incubation of BCO1 and β-carotene in H218O-16O2 or H216O-18O2 medium yields twoExpand
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Substrate Specificity of Purified Recombinant Chicken β-Carotene 9′,10′-Oxygenase (BCO2)*
Provitamin A carotenoids are oxidatively cleaved by β-carotene 15,15′-dioxygenase (BCO1) at the central 15-15′ double bond to form retinal (vitamin A aldehyde). Another carotenoid oxygenase,Expand
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Complementary shifts in photoreceptor spectral tuning unlock the full adaptive potential of ultraviolet vision in birds
Color vision in birds is mediated by four types of cone photoreceptors whose maximal sensitivities (λmax) are evenly spaced across the light spectrum. In the course of avian evolution, the λmax ofExpand
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AbstractThe long wavelength UV‐induced photoisomerization of retinoic acid has been investigated in physiologic‐like solutions. By high‐performance liquid chromatographic analysis seven isomers ofExpand
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Hepatic stellate cells are an important cellular site for β-carotene conversion to retinoid.
Hepatic stellate cells (HSCs) are responsible for storing 90-95% of the retinoid present in the liver. These cells have been reported in the literature also to accumulate dietary β-carotene, but theExpand
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