R. Coyne

Publications30
h-index20
Citations2,450
Highly Influential Citations206
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Macronuclear Genome Sequence of the Ciliate Tetrahymena thermophila, a Model Eukaryote
The ciliate Tetrahymena thermophila is a model organism for molecular and cellular biology. Like other ciliates, this species has separate germline and soma functions that are embodied by distinct… Expand
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Methylation of Histone H3 at Lysine 9 Targets Programmed DNA Elimination in Tetrahymena
Histone H3 lysine 9 methylation [Me(Lys9)H3] is an epigenetic mark for heterochromatin-dependent gene silencing, mediated by direct binding to chromodomain-containing proteins such as Heterochromatin… Expand
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Parental expression of the chromodomain protein Pdd1p is required for completion of programmed DNA elimination and nuclear differentiation.
Thousands of DNA elimination events occur during somatic differentiation of many ciliated protozoa. In Tetrahymena, the eliminated DNA aggregates into submacronuclear structures containing the… Expand
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A leucine zipper domain of the suppressor of Hairy-wing protein mediates its repressive effect on enhancer function.
The suppressor of Hairy-wing [su(Hw)] protein mediates the mutagenic effect of the gypsy retrotransposon by repressing the function of transcriptional enhancers controlling the expression of the… Expand
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Pdd1p, A Novel Chromodomain-Containing Protein, Links Heterochromatin Assembly and DNA Elimination in Tetrahymena
During Tetrahymena conjugation, programmed DNA degradation occurs in two separate nuclei. Thousands of germline-specific deletion elements are removed from the genome of the developing somatic… Expand
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The Drosophila su(Hw) gene, which controls the phenotypic effect of the gypsy transposable element, encodes a putative DNA-binding protein.
Homozygous mutations at the suppressor of Hairy-wing [su(Hw)] locus reverse the phenotype of gypsy-induced alleles in a number of genes located throughout the Drosophila genome. To understand the… Expand
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Genome downsizing during ciliate development: nuclear division of labor through chromosome restructuring.
The ciliated protozoa divide the labor of germline and somatic genetic functions between two distinct nuclei. The development of the somatic (macro-) nucleus from the germinal (micro-) nucleus occurs… Expand
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Structure of the germline genome of Tetrahymena thermophila and relationship to the massively rearranged somatic genome
The germline genome of the binucleated ciliate Tetrahymena thermophila undergoes programmed chromosome breakage and massive DNA elimination to generate the somatic genome. Here, we present a complete… Expand
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Cell shape and interaction defects in alpha-spectrin mutants of Drosophila melanogaster
We show that the alpha-spectrin gene is essential for larval survival and development by characterizing several alpha-spectrin mutations in Drosophila. P-element minigene rescue and sequence analysis… Expand
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Identification of novel chromatin-associated proteins involved in programmed genome rearrangements in Tetrahymena
Extensive DNA rearrangements occur during the differentiation of the developing somatic macronuclear genome from the germ line micronuclear genome of Tetrahymena thermophila. To identify genes… Expand
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