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The impact of retrotransposons on human genome evolution
Their ability to move within genomes gives transposable elements an intrinsic propensity to affect genome evolution. Non-long terminal repeat (LTR) retrotransposons — including LINE-1, Alu and SVAExpand
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Birth of a chimeric primate gene by capture of the transposase gene from a mobile element.
The emergence of new genes and functions is of central importance to the evolution of species. The contribution of various types of duplications to genetic innovation has been extensivelyExpand
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The impact of endosymbionts on the evolution of host sex-determination mechanisms.
The past years have revealed that inherited bacterial endosymbionts are important sources of evolutionary novelty for their eukaryotic hosts. In this review we discuss a fundamental biologicalExpand
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Analysis of gene expression from the Wolbachia genome of a filarial nematode supports both metabolic and defensive roles within the symbiosis.
The α-proteobacterium Wolbachia is probably the most prevalent, vertically transmitted symbiont on Earth. In contrast with its wide distribution in arthropods, Wolbachia is restricted to one familyExpand
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Pan-arthropod analysis reveals somatic piRNAs as an ancestral defence against transposable elements
In animals, small RNA molecules termed PIWI-interacting RNAs (piRNAs) silence transposable elements (TEs), protecting the germline from genomic instability and mutation. piRNAs have been detected inExpand
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Emergence of primate genes by retrotransposon-mediated sequence transduction
Gene duplication is one of the most important mechanisms for creating new genes and generating genomic novelty. Retrotransposon-mediated sequence transduction (i.e., the process by which aExpand
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Alu element mutation spectra: molecular clocks and the effect of DNA methylation.
In primate genomes more than 40% of CpG islands are found within repetitive elements. With more than one million copies in the human genome, the Alu family of retrotransposons represents the mostExpand
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Massive horizontal transfer of transposable elements in insects
Significance Eukaryotes normally receive their genetic material from their parents but may occasionally, like prokaryotes do, acquire DNA from unrelated organisms through horizontal transfer (HT). InExpand
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Retrotransposition of Alu elements: how many sources?
It is generally thought that only a few Alu elements are capable of retrotransposition and that these 'master' sources produce inactive copies. Here, we use a network phylogenetic approach toExpand
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Human genomic deletions mediated by recombination between Alu elements.
Recombination between Alu elements results in genomic deletions associated with many human genetic disorders. Here, we compare the reference human and chimpanzee genomes to determine the magnitude ofExpand
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