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Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray Ionization
The DESI phenomenon was observed both in the case of conductive and insulator surfaces and for compounds ranging from nonpolar small molecules such as lycopene, the alkaloid coniceine, and small drugs, through polar compounds such as peptides and proteins.
Ambient mass spectrometry using desorption electrospray ionization (DESI): instrumentation, mechanisms and applications in forensics, chemistry, and biology.
Examples of applications to small and large molecules, to in situ analysis, and to high-throughput analyses are presented and evidence is provided for both a heterogeneous charge-transfer mechanism and a droplet pick-up mechanism of ionization.
Low-temperature plasma probe for ambient desorption ionization.
A low-temperature plasma (LTP) probe has been developed for ambient desorption ionization and demonstration applications include direct analysis of cocaine from human skin, determination of active ingredients directly in drug tablets, and analysis of toxic and therapeutic compounds in complex biological samples.
Development, characterization, and application of paper spray ionization.
It is demonstrated that paper spray is applicable to the analysis of a wide variety of compounds, including small organic compounds, peptides, and proteins, as well as to mass spectrometric analysis of complex mixtures.
Electrosonic spray ionization. A gentle technique for generating folded proteins and protein complexes in the gas phase and for studying ion-molecule reactions at atmospheric pressure.
Evidence is provided that the method is capable of generating fully desolvated protein ions at atmospheric pressure and allows the technique to be used for the study of ion-molecule reactions at atmospheric Pressure.
Ambient Mass Spectrometry
A recent innovation in mass spectrometry is the ability to record mass spectra on ordinary samples, in their native environment, without sample preparation or preseparation by creating ions outside
Rectilinear ion trap: concepts, calculations, and analytical performance of a new mass analyzer.
A mass analyzer based on a rectilinear geometry ion trap (RIT) has been built, and its performance has been characterized, showing an improvement of 40 times in the signal-to-noise ratio resulting from the higher ion trapping capacity of the RIT.
Direct, trace level detection of explosives on ambient surfaces by desorption electrospray ionization mass spectrometry.
Desorption electrospray ionization (DESI) mass spectrometry is used to detect trace amounts of explosives present on a variety of ambient surfaces in 5-second analysis times without any sample
Extractive electrospray ionization for direct analysis of undiluted urine, milk and other complex mixtures without sample preparation.
On-line droplet-droplet extraction occurs when a sample spray intersects a reagent electrospray; this allows continuous analysis of trace amounts of compounds directly in complex matrices including