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R-fluoxetine Increases Extracellular DA, NE, As Well As 5-HT in Rat Prefrontal Cortex and Hypothalamus: An in vivo Microdialysis and Receptor Binding Study
- S. Koch, K. Perry, D. Nelson, R. Conway, P. Threlkeld, F. Bymaster
- Medicine, Psychology
- 1 December 2002
The pharmacologic properties of the stereoisomers using transporter and receptor binding assays and in vivo microdialysis in freely moving rats indicated a regionally selective effect of R-fluoxetine, and the unexpected increases of extracellular catecholamines by a selective 5-HT uptake inhibitors may be due to its antagonism of 5- HT2C receptors. Expand
Identification of receptor-binding residues in the inflammatory complement protein C5a by site-directed mutagenesis.
- K. Mollison, W. Mandecki, +7 authors M. Shallcross
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
Modifications of the C5a molecule causing parallel reductions in binding to polymorphonuclear leukocyte membranes and in stimulation of polymorphonnuclear leukocytes locomotion (chemokinesis) suggest that carboxyl-terminal residues Lys-68, Leu-72, and Arg-74 interact with the receptor. Expand
Behavioral Effects of a Novel Benzofuranyl-Piperazine Serotonin-2C Receptor Agonist Suggest a Potential Therapeutic Application in the Treatment of Obsessive–Compulsive Disorder
- Michelle M. Rodriguez, C. Overshiner, +6 authors J. Witkin
- Psychology, Medicine
- Front. Psychiatry
- 22 May 2017
The behavioral specificity of effects of CPD 1 against repetitive and excessive behaviors suggests a potential therapeutic application in OCD. Expand
Skeletal Muscle Regeneration and Oxidative Stress Are Altered in Chronic Kidney Disease
Data show aberrant regeneration and proteolytic signaling that is associated with oxidative stress and high levels of myostatin in the setting of CKD, which likely plays a role in the compromised skeletal muscle function that exists in CKD. Expand
Purification and characterization of a membrane-bound protein kinase from human erythrocytes.
Endogenous phosphorylation in vitro: selective effects of sacrifice methods on specific brain proteins
Endogenous phosphorylation in vitro: Differential effects of brain state (anesthesia, post-mortem) on electrophoretically separated brain proteins
The results suggest an important and perhaps unique role for Band F1 in neuronal function and evidence suggests that it may be Ca2+-dependent and that its phosphorylation is sensitive to osmotic lysis of synaptosomes. Expand
Effects of 2,3-diphosphoglyceric acid on the human erythrocyte membrane phosphorylation system.
The data indicate that 2,3-P2-glycerate may have a regulatory role in membrane protein phosphorylation and also may regulate the extent of association of the kinase with the membrane. Expand
N-(acyloxyalkyl)pyridinium salts as soluble prodrugs of a potent platelet activating factor antagonist.
- S. Davidsen, J. Summers, +6 authors G. Carter
- Chemistry, Medicine
- Journal of medicinal chemistry
- 23 December 1994
A strong correlation between prodrug structure and buffer/plasma half-life was established and the N-(acetyloxymethyl)pyridinium prodrug 11 (ABT-299) is currently undergoing clinical evaluation for the treatment of sepsis. Expand
CYCLIC AMP‐DEPENDENT PROTEIN KINASE ACTIVITY AND SYNAPTOSOMAL PROTEIN PHOSPHORYLATION IN THE BRAINS OF AGED RATS
- M. Schmidt, L. Truex, R. Conway, A. Routtenberg
- Biology, Medicine
- Journal of neurochemistry
- 1 February 1979
The studies indicate that the cyclic AMP‐dependent phosphorylation system in the rat brain does not change during advanced aging. Expand