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Serum immunoreactive-leptin concentrations in normal-weight and obese humans.
- R. Considine, M. Sinha, T. L. Bauer
- Medicine, BiologyThe New England journal of medicine
- 1 February 1996
Serum leptin concentrations are correlated with the percentage of body fat, suggesting that most obese persons are insensitive to endogenous leptin production.
Secretion of Angiogenic and Antiapoptotic Factors by Human Adipose Stromal Cells
The findings suggest that autologous delivery of either native or transduced subcutaneous ASCs, which are regulated by hypoxia, may be a novel therapeutic option to enhance angiogenesis or achieve cardiovascular protection.
Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance
Leptin: The Tale of an Obesity Gene
The discovery of a "fat-melting hormone" named leptin by Friedman raised the hopes of one-third of the U.S. population that there is a simple solution to cure their obesity and the concept of leptin resistance has since been extended to other studies in humans and to the animal models of obesity.
Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids.
Human PPAR gamma mRNA expression is most abundant in adipose tissue, but lower level expression of both splice variants is seen in skeletal muscle; to an extent that is unlikely to be due to adipose contamination.
Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice
The present findings suggest a novel paradigm for dietary fatty acids in the pathogenesis of alcoholic liver disease and provide a promising therapeutic strategy—nutritional modulation of adiponectin—in treating human alcoholic fatty liver disease.
Resistin / Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans.
It is concluded that the recently described relationships of murine resistin/Fizz3 expression with obesity, insulin resistance, and PPAR-gamma action may not readily translate to humans.
Human leptin: from an adipocyte hormone to an endocrine mediator.
- M. Wauters, R. Considine, L. V. Van Gaal
- Biology, MedicineEuropean journal of endocrinology
- 1 September 2000
Leptin may be considered a new endocrine mediator, besides its obvious role in body weight regulation, which is especially involved in glucose metabolism, as well as in normal sexual maturation and reproduction.
Responses of Leptin to Short-Term Fasting and Refeeding in Humans: A Link With Ketogenesis but Not Ketones Themselves
The study indicates that one of the adaptive physiological responses to fasting is a fall in serum leptin, although the mediator that brings about this effect remains unknown, it appears to be neither insulin nor ketones.
Gender-dependent effects of exercise training on serum leptin levels in humans.
The data suggest that 1) women have higher circulating leptin concentrations despite lower fat mass and 2) exercise training appears to have a greater effect on systemic leptin levels in females than in males.