R. Considine

Publications245
h-index70
Citations26,691
Highly Influential Citations772
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Serum immunoreactive-leptin concentrations in normal-weight and obese humans.
TLDR
Serum leptin concentrations are correlated with the percentage of body fat, suggesting that most obese persons are insensitive to endogenous leptin production.
View on PubMed
Secretion of Angiogenic and Antiapoptotic Factors by Human Adipose Stromal Cells
TLDR
The findings suggest that autologous delivery of either native or transduced subcutaneous ASCs, which are regulated by hypoxia, may be a novel therapeutic option to enhance angiogenesis or achieve cardiovascular protection.
View on Wolters Kluwer
Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance
View on Elsevier
Leptin: The Tale of an Obesity Gene
TLDR
The discovery of a "fat-melting hormone" named leptin by Friedman raised the hopes of one-third of the U.S. population that there is a simple solution to cure their obesity and the concept of leptin resistance has since been extended to other studies in humans and to the animal models of obesity.
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Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids.
TLDR
Human PPAR gamma mRNA expression is most abundant in adipose tissue, but lower level expression of both splice variants is seen in skeletal muscle; to an extent that is unlikely to be due to adipose contamination.
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Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice
TLDR
The present findings suggest a novel paradigm for dietary fatty acids in the pathogenesis of alcoholic liver disease and provide a promising therapeutic strategy—nutritional modulation of adiponectin—in treating human alcoholic fatty liver disease.
View on Wiley
Resistin / Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans.
TLDR
It is concluded that the recently described relationships of murine resistin/Fizz3 expression with obesity, insulin resistance, and PPAR-gamma action may not readily translate to humans.
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Human leptin: from an adipocyte hormone to an endocrine mediator.
TLDR
Leptin may be considered a new endocrine mediator, besides its obvious role in body weight regulation, which is especially involved in glucose metabolism, as well as in normal sexual maturation and reproduction.
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Responses of Leptin to Short-Term Fasting and Refeeding in Humans: A Link With Ketogenesis but Not Ketones Themselves
TLDR
The study indicates that one of the adaptive physiological responses to fasting is a fall in serum leptin, although the mediator that brings about this effect remains unknown, it appears to be neither insulin nor ketones.
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Gender-dependent effects of exercise training on serum leptin levels in humans.
TLDR
The data suggest that 1) women have higher circulating leptin concentrations despite lower fat mass and 2) exercise training appears to have a greater effect on systemic leptin levels in females than in males.
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