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Serum immunoreactive-leptin concentrations in normal-weight and obese humans.
- R. Considine, M. Sinha, +7 authors T. L. Bauer
- The New England journal of medicine
- 1 February 1996
BACKGROUND Leptin, the product of the ob gene, is a hormone secreted by adipocytes. Animals with mutations in the ob gene are obese and lose weight when given leptin, but little is known about the… Expand
Secretion of Angiogenic and Antiapoptotic Factors by Human Adipose Stromal Cells
Background—The delivery of autologous cells to increase angiogenesis is emerging as a treatment option for patients with cardiovascular disease but may be limited by the accessibility of sufficient… Expand
Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance
BACKGROUND A receptor for leptin has been cloned from the choroid plexus, the site of cerebrospinal-fluid (CSF) production and the location of the blood/cerebrospinal-fluid barrier. Thus, this… Expand
Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids.
- A. Vidal-Puig, R. Considine, +4 authors J. Flier
- Biology, Medicine
- The Journal of clinical investigation
- 15 May 1997
The peroxisome proliferator activated receptor (PPAR gamma) plays a key role in adipogenesis and adipocyte gene expression and is the receptor for the thiazolidinedione class of insulin-sensitizing… Expand
Leptin: The Tale of an Obesity Gene
The discovery of a "fat-melting hormone" named leptin (Greek root, leptos, meaning thin) by Friedman raised the hopes of one-third of the U.S. population that there is a simple solution to cure their… Expand
Human leptin: from an adipocyte hormone to an endocrine mediator.
- M. Wauters, R. Considine, L. V. Van Gaal
- Biology, Medicine
- European journal of endocrinology
- 1 September 2000
Leptin is a mainly adipocyte-secreted protein that was discovered 5 years ago. Most of the research following this discovery focused on the role of leptin in body weight regulation, aiming to… Expand
Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice
The protective effect of dietary saturated fatty acids against the development of alcoholic liver disease has long been known, but the underlying mechanism is not completely understood. We examined… Expand
Resistin / Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans.
Recent studies in murine models suggest that resistin (also called Fizz3 ), a novel cysteine-rich protein secreted by adipocytes, may represent the long-sought link between obesity and insulin… Expand
Obesity is associated with increased levels of circulating hepatocyte growth factor.
- J. Rehman, R. Considine, +4 authors K. March
- Journal of the American College of Cardiology
- 16 April 2003
OBJECTIVES This study evaluated whether obesity in humans was associated with an increase in circulating hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) levels. … Expand
Responses of Leptin to Short-Term Fasting and Refeeding in Humans: A Link With Ketogenesis but Not Ketones Themselves
We investigated the response of leptin to short-term fasting and refeeding in humans. A mild decline in subcutaneous adipocyte ob gene mRNA and a marked fall in serum leptin were observed after 36… Expand