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Early and protective microglial activation in Alzheimer's disease: a prospective study using 18F-DPA-714 PET imaging.
Microglial activation appears at the prodromal and possibly at the preclinical stage of Alzheimer's disease, and seems to play a protective role in the clinical progression of the disease at these early stages, according to a second-generation 18-kDa translocator protein positron emission tomography radiotracer.
Support for dopaminergic hypoactivity in restless legs syndrome: a PET study on D2-receptor binding.
The study supports involvement of the dopamine system in both striatal and extrastriatal brain regions in the pathophysiology of RLS and shows the brain regions where differences in D2-receptor binding were shown are implicated in the regulation of affective and motivational aspects of sensory processing, suggesting a possible pathway for sensory symptoms in RLS.
Evaluation of 11C-GSK189254 as a Novel Radioligand for the H3 Receptor in Humans Using PET
11C-GSK189254 can be used to quantify H3 receptor availability in humans in vivo using PET but requires high specific activity; the possibility of tracer mass dose effects should be carefully analyzed.
Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain
The results indicate that the interpretation of 18F-THK5351 PET images, with respect to tau, is confounded by the high MAO-B availability across the entire brain.
A Comparison of Gray Matter Density in Restless Legs Syndrome Patients and Matched Controls Using Voxel‐Based Morphometry
Four studies have examined structural differences between the brains of RLS patients and healthy controls, using voxel‐based morphometry (VBM).
Kinetic Modeling of the Tau PET Tracer 18F-AV-1451 in Human Healthy Volunteers and Alzheimer Disease Subjects
Although 18F-AV-1451 SUVR curves do not reach a plateau and are still increasing in AD, an SUVR calculated over an imaging window of 80–100 min provides estimates of paired helical filament tau burden in good correlation with BPND, whereas SUVR sensitivity to regional cerebral blood changes needs further investigation.