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Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Starved to Life? Caloric restriction—reducing the calories ingested by around 30% of that of a normal, fit individual—leads to substantial increases in life span in experimental animals. In anExpand
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Aspects of common marmoset basic biology and life history important for biomedical research.
While common marmosets are increasingly used as alternative primate models in biomedical research, their life history, specialized behavior and unique physiology are not well known. This paperExpand
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Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys
Caloric restriction (CR) without malnutrition increases longevity and delays the onset of age-associated disorders in short-lived species, from unicellular organisms to laboratory mice and rats. TheExpand
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Dietary restriction and aging in rhesus monkeys: the University of Wisconsin study
Dietary restriction (DR) retards aging and extends the maximum lifespan of laboratory mice and rats. To determine whether DR has similar actions in a primate species, we initiated a study in 1989 toExpand
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Caloric restriction improves health and survival of rhesus monkeys
Caloric restriction (CR) without malnutrition extends lifespan and delays the onset of age-related disorders in most species but its impact in nonhuman primates has been controversial. In the lateExpand
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Energy expenditure of rhesus monkeys subjected to 11 years of dietary restriction.
Dietary restriction (DR) is currently the only paradigm that has consistently extended maximal life span and reduced the onset of age-related chronic diseases in all of the nonprimate species tested.Expand
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Dietary restriction and glucose regulation in aging rhesus monkeys: a follow-up report at 8.5 yr.
In a longitudinal study of the effects of moderate (70%) dietary restriction (DR) on aging, plasma glucose and insulin concentrations were measured from semiannual, frequently sampled intravenousExpand
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Insights into the Development of Polycystic Ovary Syndrome (PCOS) from Studies of Prenatally Androgenized Female Rhesus Monkeys
The developmental pathophysiology of polycystic ovary syndrome (PCOS) is unknown. However, prenatally androgenized female rhesus monkeys exhibit ovarian and endocrinological features that mimic thoseExpand
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Muscle mass loss in Rhesus monkeys: Age of onset
Sarcopenia, the decline in skeletal muscle mass and function with age, contributes to increased frailty and decreased functional performance in the aging human population. The negative healthExpand
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Early-to-Mid Gestation Fetal Testosterone Increases Right Hand 2D∶4D Finger Length Ratio in Polycystic Ovary Syndrome-Like Monkeys
A smaller length ratio for the second relative to the fourth finger (2D∶4D) is repeatedly associated with fetal male-typical testosterone (T) and is implicated as a biomarker for a variety of traitsExpand
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