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A cryptic protease couples deubiquitination and degradation by the proteasome
The 26S proteasome is responsible for most intracellular proteolysis in eukaryotes. Efficient substrate recognition relies on conjugation of substrates with multiple ubiquitin molecules andExpand
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Proteasomes and their kin: proteases in the machine age
'Chambered proteases', including the eukaryotic 26S proteasome, use the energy of ATP to drive the unfolding and translocation of a polypeptide substrate into a chamber of sequestered proteolyticExpand
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Crystal Structure of a UBP-Family Deubiquitinating Enzyme in Isolation and in Complex with Ubiquitin Aldehyde
The ubiquitin-specific processing protease (UBP) family of deubiquitinating enzymes plays an essential role in numerous cellular processes. HAUSP, a representative UBP, specifically deubiquitinatesExpand
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Linkage-specific avidity defines the lysine 63-linked polyubiquitin-binding preference of rap80.
Linkage-specific polyubiquitin recognition is thought to make possible the diverse set of functional outcomes associated with ubiquitination. Thus far, mechanistic insight into this selectivity hasExpand
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The Onset of Collective Behavior in Social Amoebae
In the social amoebae Dictyostelium discoideum, periodic synthesis and release of extracellular cyclic adenosine 3 ́,5 ́-monophosphate (cAMP) guide cell aggregation and commitment to form fruitingExpand
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K63‐specific deubiquitination by two JAMM/MPN+ complexes: BRISC‐associated Brcc36 and proteasomal Poh1
An unusual deubiquitinating (DUB) activity exists in HeLa cell extracts that is highly specific for cleaving K63‐linked but not K48‐linked polyubiquitin chains. The activity is insensitive to bothExpand
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The etiology and prevalence of gingival recession.
BACKGROUND Gingival recession in its localized or generalized form is an undesirable condition resulting in root exposure. The result often is not esthetic and may lead to sensitivity and rootExpand
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Structural Insights into the Assembly and Function of the SAGA Deubiquitinating Module
Complex SAGA The SAGA (Spt-Ada-Gcn5-Acetyltransferase) complex, which is conserved in eukaryotes, plays a key role in regulating gene expression. It is comprised of 21 proteins, and its functionsExpand
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Multiscale micromechanical modeling of polymer/clay nanocomposites and the effective clay particle
Abstract Polymer/clay nanocomposites have been observed to exhibit enhanced mechanical properties at low weight fractions (Wc) of clay. Continuum-based composite modeling reveals that the enhancedExpand
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Structural basis for the specificity of ubiquitin C‐terminal hydrolases
The release of ubiquitin from attachment to other proteins and adducts is critical for ubiquitin biosynthesis, proteasomal degradation and other cellular processes. De‐ubiquitination is accomplishedExpand
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