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Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man.
BACKGROUND AND METHODS Mutations in the estrogen-receptor gene have been thought to be lethal. A 28-year-old man whose estrogen resistance was caused by a disruptive mutation in the estrogen-receptorExpand
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Cerebral glucose metabolism in adults with hyperactivity of childhood onset.
Abstract Background and Methods. The cause of childhood hyperactivity (attention deficit–hyperactivity disorder) is unknown. We investigated the hypothesis that cerebral glucose metabolism mightExpand
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Local cerebral glucose metabolic rates in obsessive-compulsive disorder. Patients treated with clomipramine.
In a recent study, we reported abnormal local cerebral glucose metabolic rates in the orbital frontal cortex of patients with obsessive-compulsive disorder. Eight patients with obsessive-compulsiveExpand
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Decreased beta-amyloid1-42 and increased tau levels in cerebrospinal fluid of patients with Alzheimer disease.
CONTEXT Alzheimer disease (AD) is characterized by pathological results at autopsy of amyloid plaques and tau-associated neurofibrillary tangles, but the clinical diagnosis of AD is determined on theExpand
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Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease
We report that a low-calorie diet can lessen the severity of neurochemical deficits and motor dysfunction in a primate model of Parkinson's disease. Adult male rhesus monkeys were maintained for 6Expand
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Obsessive-compulsive disorder. A double-blind trial of clomipramine and clorgyline.
Patients with obsessive-compulsive disorder who met DSM-III criteria and who had been ill for at least one year were studied in a double-blind, randomized, crossover comparison of the tricyclicExpand
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Cerebral glucose metabolic rates in obsessive compulsive disorder.
Brain metabolism was measured with positron emission tomography and [18F] 2-fluoro-2-deoxyglucose in normal subjects and in patients with obsessive compulsive disorder (OCD) while they performed aExpand
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Effect of apolipoprotein E genotype on hippocampal volume loss in aging healthy women
Objective: To determine whether the presence of a single ε4 allele of the APOE gene is associated with an increased rate of hippocampal volume loss or decline in cognition in healthy women in theirExpand
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Positron-Emission Tomography and Personality Disorders
This study used positron-emission tomography to examine cerebral metabolic rates of glucose (CMRG) in 17 patients with DSM III-R diagnoses of personality disorder. Within the group of 17 personalityExpand
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High midbrain [18F]DOPA accumulation in children with attention deficit hyperactivity disorder.
OBJECTIVE Attention deficit hyperactivity disorder (ADHD) is a highly prevalent childhood psychiatric disorder characterized by impaired attention, excessive motor activity, and impulsivity. DespiteExpand
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