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- Publications
- Influence
Interleukin-6, a mental cytokine
- Anneleen Spooren, K. Kolmus, Guy Laureys, R. Clinckers, S. Gerlo
- Medicine
- Brain Research Reviews
- 24 June 2011
Almost a quarter of a century ago, interleukin-6 (IL-6) was discovered as an inflammatory cytokine involved in B cell differentiation. Today, IL-6 is recognized to be a highly versatile cytokine,… Expand
Validation of the Zebrafish Pentylenetetrazol Seizure Model: Locomotor versus Electrographic Responses to Antiepileptic Drugs
- T. Afrikanova, A. Serruys, +5 authors Camila V Esguerra
- Biology, Medicine
- PloS one
- 14 January 2013
Zebrafish have recently emerged as an attractive in vivo model for epilepsy. Seven-day-old zebrafish larvae exposed to the GABAA antagonist pentylenetetrazol (PTZ) exhibit increased locomotor… Expand
Increased hippocampal noradrenaline is a biomarker for efficacy of vagus nerve stimulation in a limbic seizure model
- R. Raedt, R. Clinckers, +10 authors A. Meurs
- Medicine
- Journal of neurochemistry
- 1 May 2011
J. Neurochem. (2011) 117, 461–469.
White-Matter Astrocytes, Axonal Energy Metabolism, and Axonal Degeneration in Multiple Sclerosis
- M. Cambron, M. D'haeseleer, Guy Laureys, R. Clinckers, J. Debruyne, J. De Keyser
- Biology, Medicine
- Journal of cerebral blood flow and metabolism…
- 1 March 2012
In patients with multiple sclerosis (MS), a diffuse axonal degeneration occurring throughout the white matter of the central nervous system causes progressive neurologic disability. The underlying… Expand
Seizure activity and changes in hippocampal extracellular glutamate, GABA, dopamine and serotonin
- A. Meurs, R. Clinckers, G. Ebinger, Y. Michotte, I. Smolders
- Chemistry, Medicine
- Epilepsy Research
- 31 January 2008
Increases in hippocampal extracellular neurotransmitter levels have consistently been observed during temporal lobe seizures in humans, but animal studies on this subject have yielded conflicting… Expand
Anticonvulsant action of hippocampal dopamine and serotonin is independently mediated by D2 and 5‐HT1A receptors
- R. Clinckers, I. Smolders, A. Meurs, G. Ebinger, Y. Michotte
- Chemistry, Medicine
- Journal of neurochemistry
- 1 May 2004
The present microdialysis study evaluated the anticonvulsant activity of extracellular hippocampal dopamine (DA) and serotonin (5‐HT) with concomitant assessment of the possible mutual interactions… Expand
Direct enhancement of hippocampal dopamine or serotonin levels as a pharmacodynamic measure of combined antidepressant–anticonvulsant action
- I. Smolders, R. Clinckers, A. Meurs, D. D. Bundel, Y. Michotte
- Psychology, Medicine
- Neuropharmacology
- 1 May 2008
The neurobiological relationships between epilepsy and depression are receiving increased experimental attention. A key role for limbic monoamines in depression has been established and we recently… Expand
Quantitative in Vivo Microdialysis Study on the Influence of Multidrug Transporters on the Blood-Brain Barrier Passage of Oxcarbazepine: Concomitant Use of Hippocampal Monoamines as Pharmacodynamic…
- R. Clinckers, I. Smolders, A. Meurs, G. Ebinger, Y. Michotte
- Chemistry, Medicine
- Journal of Pharmacology and Experimental…
- 1 August 2005
Various antiepileptic drugs were shown to be substrates for multidrug transporters at the level of the blood-brain barrier. These ATP-dependent efflux pumps actively limit brain accumulation of… Expand
Anticonvulsant action of GBR-12909 and citalopram against acute experimentally induced limbic seizures
- R. Clinckers, I. Smolders, A. Meurs, G. Ebinger, Y. Michotte
- Chemistry, Medicine
- Neuropharmacology
- 1 December 2004
We recently showed that intrahippocampally administered dopamine and serotonin exert concentration-dependent non-protective, protective and proconvulsant effects against limbic seizures in rats.… Expand
Hippocampal dopamine and serotonin elevations as pharmacodynamic markers for the anticonvulsant efficacy of oxcarbazepine and 10,11-dihydro-10-hydroxycarbamazepine
- R. Clinckers, I. Smolders, A. Meurs, G. Ebinger, Y. Michotte
- Chemistry, Medicine
- Neuroscience Letters
- 16 December 2005
We recently showed that dopamine (DA) and serotonin (5-HT) exert anticonvulsant effects against limbic seizures in rats mediated by hippocampal D(2) and 5-HT(1A) receptor stimulation. For exogenously… Expand
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