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Anti-inflammatory and immunosuppressive drugs and reproduction
Rheumatic diseases in women of childbearing years may necessitate drug treatment during a pregnancy, to control maternal disease activity and to ensure a successful pregnancy outcome. This survey is… Expand
Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling
The type I interferon system is integral to human antiviral immunity. However, inappropriate stimulation or defective negative regulation of this system can lead to inflammatory disease. We sought to… Expand
Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment.
- K. Nistala, S. Adams, +7 authors L. Wedderburn
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 17 August 2010
In several murine models of autoimmune arthritis, Th17 cells are the dominant initiators of inflammation. In human arthritis the majority of IL-17-secreting cells within the joint express a cytokine… Expand
Two randomized trials of canakinumab in systemic juvenile idiopathic arthritis.
- N. Ruperto, H. Brunner, +33 authors D. Lovell
- The New England journal of medicine
- 19 December 2012
BACKGROUND Interleukin-1 is pivotal in the pathogenesis of systemic juvenile idiopathic arthritis (JIA). We assessed the efficacy and safety of canakinumab, a selective, fully human,… Expand
Distinctive features of classic and nonclassic (Th17 derived) human Th1 cells
- L. Maggi, V. Santarlasci, +10 authors F. Annunziato
- Biology, Medicine
- European journal of immunology
- 1 December 2012
T helper17 (Th17) lymphocytes represent a third arm of the CD4+ T‐cell effector responses, in addition to Th1 and Th2 cells. Th17 cells have been found to exhibit high plasticity because they rapidly… Expand
Evidence of the transient nature of the Th17 phenotype of CD4+CD161+ T cells in the synovial fluid of patients with juvenile idiopathic arthritis.
OBJECTIVE To investigate the phenotype and function of CD4+ T cells in synovial fluid (SF) from the affected joints of children with oligoarticular-onset juvenile idiopathic arthritis (JIA), and to… Expand
Neonatal lupus syndromes.
- R. Cimaz, L. Catelli, C. Luzzana, P. Panzeri, P. Meroni
- The Israel Medical Association journal : IMAJ
- 1 March 2000
Abstract Neonatal lupus is an in vivo model of acquired autoimmune disease in which anti-Ro/SSA autoantibodies are transmitted through the placenta from a mother to her fetus. The most important… Expand
Risk of congenital complete heart block in newborns of mothers with anti-Ro/SSA antibodies detected by counterimmunoelectrophoresis: a prospective study of 100 women.
OBJECTIVE To assess the true prevalence of congenital complete heart block (CCHB) in infants of anti-Ro/SSA-positive women known to have connective tissue disease (CTD) and, secondarily, to evaluate… Expand
Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease
Kawasaki disease is a systemic vasculitis of unknown etiology, with clinical observations suggesting a substantial genetic contribution to disease susceptibility. We conducted a genome-wide… Expand
Caveats and truths in genetic, clinical, autoimmune and autoinflammatory issues in Blau syndrome and early onset sarcoidosis.
Blau syndrome (BS) and early onset sarcoidosis (EOS) are, respectively, the familial and sporadic forms of the pediatric granulomatous autoinflammatory disease, which belong to the group of monogenic… Expand