Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
- Jodie L Babitt, F. Huang, Herbert Y. Lin
- Biology, MedicineNature Genetics
- 9 April 2006
Hemojuvelin is a BMP coreceptor and that hemojuvelin mutants associated with hemochromatosis have impaired BMP signaling ability, and BMP upregulates hepatocyte hepcidin expression, a process enhanced by hemoJuvelin and blunted in Hfe2−/− hepatocytes.
Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus
- F. Lechner, D. Wong, B. Walker
- Medicine, BiologyJournal of Experimental Medicine
- 1 May 2000
A strong and persistent CTL response in resolving acute HCV infection is demonstrated, and rationale to explore immune augmentation as a therapeutic intervention in chronic HCv infection is provided.
A functional genomic screen identifies cellular cofactors of hepatitis C virus replication.
- A. Tai, Yair Benita, R. Chung
- Biology, MedicineCell Host and Microbe
- 19 March 2009
Peginterferon Alfa-2a plus ribavirin versus interferon alfa-2a plus ribavirin for chronic hepatitis C in HIV-coinfected persons.
- R. Chung, J. Andersen, C. M. van der Horst
- MedicineNew England Journal of Medicine
- 29 July 2004
The marked discrepancy in the rates of sustained virologic response between HCV genotypes indicates that strategies are needed to improve the outcome in persons infected withHCV genotype 1.
A role for hepatitis C virus infection in type II cryoglobulinemia.
- V. Agnello, R. Chung, L. Kaplan
- Medicine, BiologyNew England Journal of Medicine
- 19 November 1992
Type II cryoglobulinemia is strongly associated with concomitant HCV infection and a high rate of false negative serologic tests, suggesting a role for HCV in the pathogenesis of mixed cryoglOBulinemi.
Hepatitis C Virus prevalence among patients infected with Human Immunodeficiency Virus: a cross-sectional analysis of the US adult AIDS Clinical Trials Group.
- K. Sherman, S. Rouster, R. Chung, N. Rajicic
- Medicine, BiologyClinical Infectious Diseases
- 15 March 2002
High virus loads and genotype 1 prevalence may be important to interferon-based antiviral response rates among coinfected patients.
The epigenetic landscape of T cell exhaustion
- Debattama R. Sen, James Kaminski, W. Haining
- BiologyScience
- 2 December 2016
The accessible chromatin landscape in exhausted CD8+ T cells is defined and shown that it is distinct from functional memory CD8 + T cells, suggesting that exhausted T cells are a distinct lineage.
POSTTRANSPLANT DIABETES MELLITUS IN LIVER TRANSPLANT RECIPIENTS: RISK FACTORS, TEMPORAL RELATIONSHIP WITH HEPATITIS C VIRUS ALLOGRAFT HEPATITIS, AND IMPACT ON MORTALITY1
- S. Baid, A. Cosimi, M. Pascual
- Medicine, BiologyTransplantation
- 27 September 2001
A high prevalence of PTDM was found in HCV (+) recipients and PTDM after OLT was associated with significantly increased mortality, and HCV infection and methylprednisolone boluses were found to be independent risk factors for the developed PTDM.
Clinical Best Practice Advice for Hepatology and Liver Transplant Providers During the COVID‐19 Pandemic: AASLD Expert Panel Consensus Statement
The aim is to provide a template for the development of clinical recommendations and policies to mitigate the impact of the COVID‐19 pandemic on liver patients and healthcare providers.
High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection.
- G. Lauer, E. Barnes, P. Klenerman
- Biology, MedicineGastroenterology
- 1 September 2004
Data indicate that persisting, strong CD8+ T-cell responses are observed in the majority of persons with resolved HCV infection and provide support for strategies to boost CD8+, but also highlight the diversity of responses that may need to be elicited to provide protection.
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