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- Publications
- Influence
Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma
- R. Chiu, K. Chan, +11 authors Y. M. D. Lo
- Medicine, Biology
- Proceedings of the National Academy of Sciences
- 23 December 2008
Chromosomal aneuploidy is the major reason why couples opt for prenatal diagnosis. Current methods for definitive diagnosis rely on invasive procedures, such as chorionic villus sampling and… Expand
Hypermethylated RASSF1A in maternal plasma: A universal fetal DNA marker that improves the reliability of noninvasive prenatal diagnosis.
- K. Chan, Chunming Ding, +8 authors Y. Lo
- Medicine, Biology
- Clinical chemistry
- 1 December 2006
BACKGROUND
We recently demonstrated that the promoter of the RASSF1A gene is hypermethylated in the placenta and hypomethylated in maternal blood cells. This methylation pattern allows the use of… Expand
Microfluidics digital PCR reveals a higher than expected fraction of fetal DNA in maternal plasma.
- Fiona M. F. Lun, R. Chiu, K. Chan, T. Y. Leung, T. Lau, Y. M. D. Lo
- Medicine, Biology
- Clinical chemistry
- 1 October 2008
BACKGROUND
The precise measurement of cell-free fetal DNA in maternal plasma facilitates noninvasive prenatal diagnosis of fetal chromosomal aneuploidies and other applications. We tested the… Expand
Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients
- N. Lee, K. A. Allen Chan, +11 authors Y. M. D. Lo
- Medicine
- Journal of Clinical Virology
- 11 September 2004
Abstract
Background:
The effect of corticosteroid treatment on the viral load of Severe Acute Respiratory Syndrome (SARS) patients… Expand
Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study
- R. Chiu, R. Akolekar, +21 authors Y. Lo
- Medicine
- BMJ : British Medical Journal
- 11 January 2011
Objectives To validate the clinical efficacy and practical feasibility of massively parallel maternal plasma DNA sequencing to screen for fetal trisomy 21 among high risk pregnancies clinically… Expand
mRNA of placental origin is readily detectable in maternal plasma
- E. K. Ng, N. Tsui, +6 authors Y. Lo
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 18 March 2003
The discovery of circulating fetal nucleic acid in maternal plasma has opened up new possibilities for noninvasive prenatal diagnosis. Thus far, a gender- and polymorphism-independent fetal-specific… Expand
Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection
- Y. Lo, N. Tsui, +8 authors Chunming Ding
- Medicine
- Nature Medicine
- 1 February 2007
Current methods for prenatal diagnosis of chromosomal aneuploidies involve the invasive sampling of fetal materials using procedures such as amniocentesis or chorionic villus sampling and constitute… Expand
Size-based molecular diagnostics using plasma DNA for noninvasive prenatal testing
- Stephanie C Y Yu, K. Chan, +12 authors Y. Lo
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 19 May 2014
Significance Noninvasive prenatal testing (NIPT) using fetal DNA in maternal plasma has been rapidly adopted worldwide. Current NIPT for fetal chromosomal disorders are based on the counting of DNA… Expand
Noninvasive Prenatal Diagnosis of Fetal Trisomy 18 and Trisomy 13 by Maternal Plasma DNA Sequencing
Massively parallel sequencing of DNA molecules in the plasma of pregnant women has been shown to allow accurate and noninvasive prenatal detection of fetal trisomy 21. However, whether the sequencing… Expand
Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients
- P. Jiang, Carol W M Chan, +10 authors Y. Lo
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 2 February 2015
Significance We used massively parallel sequencing to study the size profiles of plasma DNA samples at single-base resolution and in a genome-wide manner. We used chromosome arm-level z-score… Expand