R. Cherniak

Publications86
h-index33
Citations3,353
Highly Influential Citations109
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Cryptococcus neoformans Chemotyping by Quantitative Analysis of 1H Nuclear Magnetic Resonance Spectra of Glucuronoxylomannans with a Computer-Simulated Artificial Neural Network
ABSTRACT The complete assignment of the proton chemical shifts obtained by nuclear magnetic resonance (NMR) spectroscopy of de-O-acetylated glucuronoxylomannans (GXMs) from Cryptococcus… Expand
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Microevolution of a Standard Strain ofCryptococcus neoformans Resulting in Differences in Virulence and Other Phenotypes
ABSTRACT Cryptococcus neoformans is a major fungal pathogen for patients with debilitated immune systems. However, no information is available on the stability of virulence or of phenotypes… Expand
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Polysaccharide antigens of the capsule of Cryptococcus neoformans.
The major significance of the capsular polysaccharide of C. neoformans is its role in potentiating opportunistic infections by the yeast. It has the ability to exert a broad spectrum of influences on… Expand
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A galactoxylomannan antigen of Cryptococcus neoformans serotype A
Abstract The capsular polysaccharide of Cryptococcus neoformans serotype A was fractionated into two chemically and serologically distinct heteroglycans by differential precipitation with… Expand
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Cell-wall glucans of Cryptococcus neoformans Cap 67.
Purified cell walls derived from Cryptococcus neofromans Cap 67, an acapsular mutant, consisted of 86% Glc and 7.3% GlcNAc. The integrity of the cell walls was disrupted in three successive… Expand
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Structural characterization of the galactoxylomannan of Cryptococcus neoformans Cap67.
The galactoxylomannan (GalXM) obtained from the culture supernatant of an acapsular mutant of Cryptococcus neoformans Cap67 was purified by Concanavalin A affinity, ion-exchange, and gel-filtration… Expand
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Structure and antigenic activity of the capsular polysaccharide of Cryptococcus neoformans serotype A.
Abstract The glucuronoxylomannan (GXM) of C. neoformans serotype A contained molar ratios of xylose: mannose: glucuronic acid: O -acetyl of 2:5:1:2. The xylose and glucuronic acid occurred as single… Expand
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Induction of TNF-alpha in human peripheral blood mononuclear cells by the mannoprotein of Cryptococcus neoformans involves human mannose binding protein.
We have shown previously that specific receptors on PBMCs and a serum factor other than Ab and complement are involved in the TNF-alpha response to cryptococcal mannoprotein (MP2). To characterize… Expand
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Fractionation and characterization of galactoxylomannan from Cryptococcus neoformans.
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Biochemical characterization of Candida albicans epitopes that can elicit protective and nonprotective antibodies.
We previously reported that the immunoglobulin M (IgM) monoclonal antibody (MAb) B6.1 protects mice against disseminated candidiasis, whereas the IgM MAb B6 does not. Both MAbs are specific for an… Expand
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