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  • Influence
Fanconi Anemia Signaling and Cancer.
The extremely high cancer incidence associated with patients suffering from a rare human genetic disease, Fanconi anemia (FA), demonstrates the importance of FA genes. Over the course of human tumorExpand
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Multifaceted Fanconi Anemia Signaling.
In 1927 Guido Fanconi described a hereditary condition presenting panmyelopathy accompanied by short stature and hyperpigmentation, now better known as Fanconi anemia (FA). With this discovery theExpand
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FANCD2 and DNA Damage
Investigators have dedicated considerable effort to understanding the molecular basis underlying Fanconi Anemia (FA), a rare human genetic disease featuring an extremely high incidence of cancer andExpand
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Overlooked FANCD2 variant encodes a promising, portent tumor suppressor, and alternative polyadenylation contributes to its expression
Fanconi Anemia (FA) complementation group D2 protein (FANCD2) is the center of the FA tumor suppressor pathway, which has become an important field of investigation in human aging and cancer. Here weExpand
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DNA methylation of METTL7A gene body regulates its transcriptional level in thyroid cancer
DNA methylation is the best-studied epigenetic mechanism for regulating gene transcription and maintaining genome stability. Current research progress of transcriptional regulation by DNA methylationExpand
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Distinct Metabolic Signature of Human Bladder Cancer Cells Carrying an Impaired Fanconi Anemia Tumor-Suppressor Signaling Pathway.
Metabolic profiling has great potential to help the diagnosis and prognosis of cancer patients. Fanconi Anemia (FA) tumor-suppressor signaling has been instrumental in understanding humanExpand
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BLM promotes the activation of Fanconi Anemia signaling pathway
Mutations in the human RecQ helicase, BLM, causes Bloom Syndrome, which is a rare autosomal recessive disorder and characterized by genomic instability and an increased risk of cancer. Fanconi AnemiaExpand
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Involvement of FANCD2 in Energy Metabolism via ATP5α
Growing evidence supports a general hypothesis that aging and cancer are diseases related to energy metabolism. However, the involvement of Fanconi Anemia (FA) signaling, a unique genetic modelExpand
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Fanconi Anemia Group D2 Protein Participates in Replication Origin Firing.
In the past decade, our laboratory has been greatly interested in studying the Fanconi Anemia (FA) signaling pathway [1-5]. This interest stems from the ability of the FA pathway to maintain genomeExpand
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Fanconi Anemia Signaling: The Role of FANCD2 During M Phase.
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