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Environmental and epigenetic effects upon preimplantation embryo metabolism and development
In vitro fertilization has provided a unique window into the metabolic processes that drive embryonic growth and development from a fertilized ovum to a competent blastocyst. Post-fertilizationExpand
Novel hormone treatment of benign metastasizing leiomyoma: an analysis of five cases and literature review.
OBJECTIVE To evaluate novel hormonal therapies in patients with unresectable benign metastasizing leiomyoma (BML) disease. DESIGN Case series. SETTING National Institutes of Health (NIH). Expand
GnRH antagonist rescue in high responders at risk for OHSS results in excellent assisted reproduction outcomes.
Gonadotrophin-releasing hormone (GnRH) antagonist rescue is performed by replacing a GnRH agonist with a GnRH antagonist in patients with rapidly rising serum oestradiol who are at risk of ovarianExpand
Are intracytoplasmic sperm injection and high serum estradiol compounding risk factors for adverse obstetric outcomes in assisted reproductive technology?
OBJECTIVE To evaluate whether intracytoplasmic sperm injection (ICSI) use and E2 on the final day of assisted reproductive technology (ART) stimulation are associated with adverse obstetricExpand
Activating transcription factor 3 gene expression suggests that tissue stress plays a role in leiomyoma development.
OBJECTIVE To determine whether expression of the stress response gene ATF3 and related members of activator protein complex-1, cJun and cFos, were altered in leiomyoma compared with myometrium, andExpand
Experience with a patient-friendly, mandatory, single-blastocyst transfer policy: the power of one.
OBJECTIVE To determine whether a mandatory single-blastocyst transfer (mSBT) algorithm reduced multiple gestation rates without sacrificing clinical pregnancy rates. DESIGN Retrospective review. Expand
Impact of a prior cesarean delivery on embryo transfer: a prospective study.
OBJECTIVE To determine whether a history of prior cesarean delivery (CD) makes ET more difficult and impacts pregnancy outcomes. DESIGN Prospective cohort study. SETTING Tertiary care militaryExpand
Preconception stress and the secondary sex ratio: a prospective cohort study.
OBJECTIVE To study the association between salivary stress biomarkers and the secondary sex ratio. DESIGN Prospective, longitudinal cohort study. SETTING Community setting in the United Kingdom.Expand
GnRH agonist reduces estrogen receptor dimerization in GT1-7 cells: Evidence for cross-talk between membrane-initiated estrogen and GnRH signaling
17β-estradiol (E2), a key participant on the initiation of the LH surge, exerts both positive and negative feedback on GnRH neurons. We sought to investigate potential interactions between estrogenExpand