• Publications
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NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate.
Robert Kavlock a, Kim Boekelheide b, Robert Chapin c, Michael Cunningham c, Elaine Faustman d, Paul Foster e, Mari Golub f, Rogene Henderson g, Irwin Hinberg h, Ruth Little c, Jennifer Seed i,Expand
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NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A.
Robert E. Chapin, Jane Adams, Kim Boekelheide, L. Earl Gray Jr, Simon W. Hayward, Peter S.J. Lees, Barry S. McIntyre, Kenneth M. Portier, Teresa M. Schnorr, Sherry G. Selevan, John G. Vandenbergh,Expand
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Recommended Approaches for the Evaluation of Testicular and Epididymal Toxicity
BioReliance Corporation, Rockville, Maryland, 20850 Huntingdon Life Sciences, East Millstone, New Jersey 08875 Pfizer Inc, Groton, Connecticut 06340 Experimental Pathology Laboratory NorthEast,Expand
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The effects of 4-nonylphenol in rats: a multigeneration reproduction study.
The alkylphenol breakdown products of alkylphenol ethoxylates have been shown in in vitro studies to be weakly estrogenic, but few in vivo data address this issue in mammals. Because estrogens haveExpand
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Adhesion and signaling proteins spatiotemporally associated with spermiation in the rat.
Spermiation, the process by which late spermatids separate from the Sertoli cell, is disrupted by a number of toxicants. In this study, we used immunohistochemistry (IHC) to identify some of theExpand
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The effects of perinatal/juvenile methoxychlor exposure on adult rat nervous, immune, and reproductive system function.
In order to address data gaps identified by the NAS report Pesticides in the Diets of Infants and Children, a study was performed using methoxychlor (MXC). Female rats were gavaged with MXC at 0, 5,Expand
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NTP-CERHR Expert Panel Update on the Reproductive and Developmental Toxicity of di(2-ethylhexyl) phthalate.
Robert Kavlock a, Dana Barr b, Kim Boekelheide c, William Breslin d, Patrick Breysse e,1, Robert Chapin f, Kevin Gaido g, Ernest Hodgson h, Michele Marcus i,1, Katherine Shea j,1, Paige Williams k aExpand
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Leydig cell hyperplasia and adenoma formation: mechanisms and relevance to humans.
Leydig cell adenomas are observed frequently in studies evaluating the chronic toxicity of chemical agents in laboratory animals. Doubts have been raised about the relevance of such responses forExpand
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Results and evaluations of 48 continuous breeding reproduction studies conducted in mice.
Results of 48 continuous breeding reproduction (RACB) studies are summarized and control data from these studies are used to determine the statistical sensitivity of each endpoint from differentExpand
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