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Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research.
TLDR
It is hypothesized that modulation of signaling pathways and neuronal properties during RA-mediated differentiation in SH-SY5Y cells can affect their susceptibility to neurotoxins, and undifferentiated SH- SY5Y is more appropriate for studying neurotoxicity or neuroprotection in experimental Parkinson's disease research. Expand
Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease.
TLDR
It is concluded that phosphorylation of eIF2alpha is associated with the degeneration of neurons in AD. Expand
Phosphorylation of eukaryotic initiation factor-2α (eIF2α) is associated with neuronal degeneration in Alzheimer's disease
TLDR
It is concluded that phosphorylation of eIF2alpha is associated with the degeneration of neurons in AD. Expand
Involvement of double‐stranded RNA‐dependent protein kinase and phosphorylation of eukaryotic initiation factor‐2α in neuronal degeneration
TLDR
It is shown that PKR activation and eIF2α phosphorylation play a significant role in apoptosis of neuroblastoma cells and primary neuronal cultures induced by the β‐amyloid peptides, the calcium ionophore A23187 and flavonoids and could be a new target in neuroprotection. Expand
Metabolic changes in the anterior and posterior cingulate cortices of the normal aging brain: proton magnetic resonance spectroscopy study at 3 T
TLDR
The results showed significant positive correlation of choline and creatine increases with age, which could be compensatory to an increased energy demand coupled with a lower cerebral blood flow and an increase in N-acetyl-aspartate might indicate neuronal hypertrophy. Expand
Neuroprotective effects of anti-aging oriental medicine Lycium barbarum against β-amyloid peptide neurotoxicity
TLDR
Investigation of natural plant extracts of Lycium barbarum aimed to investigate whether extracts from L. barbarum have neuroprotective effects against toxicity of fibrillar Abeta(1-42) and Abeta (25-35) fragments proved the hypothesis by showing neuroprot protective effects of the extract. Expand
Dietary oxyresveratrol prevents parkinsonian mimetic 6-hydroxydopamine neurotoxicity.
TLDR
OXY, a dietary phenolic compound, is suggested as a potential nutritional candidate for protection against neurodegeneration in PD by suggesting that OXY may act as an intracellular antioxidant to reduce oxidative stress induced by 6-OHDA. Expand
Calcium dysregulation in Alzheimer's disease: From mechanisms to therapeutic opportunities
TLDR
An overview of the current understanding of the molecular mechanisms involved in calcium dysregulation in AD, and an insight on how to exploit calcium regulation as therapeutic opportunities in AD are provided. Expand
The putative neurodegenerative links between depression and Alzheimer's disease
TLDR
The putative links between AD and depression are discussed, with a number of proposed mechanisms for depression appear to be similar to those implicated in neurodegenerative diseases, including AD. Expand
Lycium Barbarum Polysaccharides Reduce Neuronal Damage, Blood-Retinal Barrier Disruption and Oxidative Stress in Retinal Ischemia/Reperfusion Injury
TLDR
It is suggested that LBP may have a neuroprotective role to play in ocular diseases for which I/R is a feature and pre-treatment with LBP for 1 week effectively protected the retina from neuronal death, apoptosis, glial cell activation, aquaporin water channel up-regulation, disruption of BRB and oxidative stress. Expand
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