R. Chan

Publications277
h-index38
Citations11,821
Highly Influential Citations530
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Biological Insights From 108 Schizophrenia-Associated Genetic Loci
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association… Expand
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Assessment of executive functions: review of instruments and identification of critical issues.
"Executive functions" is an umbrella term for functions such as planning, working memory, inhibition, mental flexibility, as well as the initiation and monitoring of action. The impairment of… Expand
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Facial emotion processing in schizophrenia: a meta-analysis of functional neuroimaging data.
BACKGROUND People with schizophrenia have difficulty with emotion perception. Functional imaging studies indicate regional brain activation abnormalities in patients with schizophrenia when… Expand
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Resting-state functional connectivity in treatment-resistant depression.
OBJECTIVE The authors used resting-state functional connectivity MRI to evaluate brain networks in patients with refractory and nonrefractory major depressive disorder. METHOD In a cross-sectional… Expand
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A meta‐analysis of association studies between the 10‐repeat allele of a VNTR polymorphism in the 3′‐UTR of dopamine transporter gene and attention deficit hyperactivity disorder
The association between the 10‐repeat allele of the dopamine transporter gene (DAT) and attention deficit hyperactivity disorder (ADHD) is uncertain. This study aimed to conduct a meta‐analysis of… Expand
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Brain anatomical abnormalities in high-risk individuals, first-episode, and chronic schizophrenia: an activation likelihood estimation meta-analysis of illness progression.
OBJECTIVE The present study reviewed voxel-based morphometry (VBM) studies on high-risk individuals with schizophrenia, patients experiencing their first-episode schizophrenia (FES), and those with… Expand
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Neurological soft signs are not "soft" in brain structure and functional networks: evidence from ALE meta-analysis.
BACKGROUND Neurological soft signs (NSS) are associated with schizophrenia and related psychotic disorders. NSS have been conventionally considered as clinical neurological signs without localized… Expand
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Short-term effects of antipsychotic treatment on cerebral function in drug-naive first-episode schizophrenia revealed by "resting state" functional magnetic resonance imaging.
  • S. Lui, T. Li, +12 authors Q. Gong
  • Psychology, Medicine
  • Archives of general psychiatry
  • 1 August 2010
CONTEXT Most of what we know about antipsychotic drug effects is at the receptor level, distal from the neural system effects that mediate their clinical efficacy. Studying cerebral function in… Expand
  • 287
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Is depression a disconnection syndrome? Meta-analysis of diffusion tensor imaging studies in patients with MDD.
BACKGROUND Many studies using diffusion tensor imaging (DTI) have demonstrated impaired white matter integrity in patients with major depressive disorder (MDD), with significant results found in… Expand
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Cross-cultural validation of the Depression Anxiety Stress Scale-21 in China.
The gap between the demand and delivery of mental health services in mainland China can be reduced by validating freely available and psychometrically sound psychological instruments. The present… Expand
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