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Biological Insights From 108 Schizophrenia-Associated Genetic Loci
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association… Expand
Assessment of executive functions: review of instruments and identification of critical issues.
- R. Chan, D. Shum, T. Toulopoulou, E. Y. Chen
- Medicine, Psychology
- Archives of clinical neuropsychology : the…
- 1 March 2008
"Executive functions" is an umbrella term for functions such as planning, working memory, inhibition, mental flexibility, as well as the initiation and monitoring of action. The impairment of… Expand
Facial emotion processing in schizophrenia: a meta-analysis of functional neuroimaging data.
BACKGROUND People with schizophrenia have difficulty with emotion perception. Functional imaging studies indicate regional brain activation abnormalities in patients with schizophrenia when… Expand
Resting-state functional connectivity in treatment-resistant depression.
- S. Lui, Qi-zhu Wu, +7 authors Q. Gong
- Psychology, Medicine
- The American journal of psychiatry
- 1 June 2011
OBJECTIVE The authors used resting-state functional connectivity MRI to evaluate brain networks in patients with refractory and nonrefractory major depressive disorder. METHOD In a cross-sectional… Expand
A meta‐analysis of association studies between the 10‐repeat allele of a VNTR polymorphism in the 3′‐UTR of dopamine transporter gene and attention deficit hyperactivity disorder
- B. Yang, R. Chan, J. Jing, T. Li, P. Sham, R. Y. Chen
- Biology, Medicine
- American journal of medical genetics. Part B…
- 5 June 2007
The association between the 10‐repeat allele of the dopamine transporter gene (DAT) and attention deficit hyperactivity disorder (ADHD) is uncertain. This study aimed to conduct a meta‐analysis of… Expand
Brain anatomical abnormalities in high-risk individuals, first-episode, and chronic schizophrenia: an activation likelihood estimation meta-analysis of illness progression.
OBJECTIVE The present study reviewed voxel-based morphometry (VBM) studies on high-risk individuals with schizophrenia, patients experiencing their first-episode schizophrenia (FES), and those with… Expand
Neurological soft signs are not "soft" in brain structure and functional networks: evidence from ALE meta-analysis.
BACKGROUND Neurological soft signs (NSS) are associated with schizophrenia and related psychotic disorders. NSS have been conventionally considered as clinical neurological signs without localized… Expand
Short-term effects of antipsychotic treatment on cerebral function in drug-naive first-episode schizophrenia revealed by "resting state" functional magnetic resonance imaging.
CONTEXT Most of what we know about antipsychotic drug effects is at the receptor level, distal from the neural system effects that mediate their clinical efficacy. Studying cerebral function in… Expand
Is depression a disconnection syndrome? Meta-analysis of diffusion tensor imaging studies in patients with MDD.
- Yi Liao, X. Huang, +8 authors Q. Gong
- Psychology, Medicine
- Journal of psychiatry & neuroscience : JPN
BACKGROUND Many studies using diffusion tensor imaging (DTI) have demonstrated impaired white matter integrity in patients with major depressive disorder (MDD), with significant results found in… Expand
Cross-cultural validation of the Depression Anxiety Stress Scale-21 in China.
The gap between the demand and delivery of mental health services in mainland China can be reduced by validating freely available and psychometrically sound psychological instruments. The present… Expand