R. Chan

Publications326
h-index44
Citations15,016
Highly Influential Citations605
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Biological Insights From 108 Schizophrenia-Associated Genetic Loci
TLDR
Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.
Assessment of executive functions: review of instruments and identification of critical issues.
Resting-state functional connectivity in treatment-resistant depression.
TLDR
The results suggest that nonrefractory and refractory depression are characterized by distinct functional deficits in distributed brain networks.
Facial emotion processing in schizophrenia: a meta-analysis of functional neuroimaging data.
TLDR
A marked underrecruitment of the amygdala, accompanied by a substantial limitation in activation throughout a ventral temporal-basal ganglia-prefrontal cortex "social brain" system may be central to the difficulties patients experience when processing facial emotion.
Cross-cultural validation of the Depression Anxiety Stress Scale-21 in China.
TLDR
Findings in two studies support the cross-cultural validity of the Chinese version of the 21-item Depression Anxiety Stress Scales (DASS-21), which has potential clinical utility in mainland China.
A meta‐analysis of association studies between the 10‐repeat allele of a VNTR polymorphism in the 3′‐UTR of dopamine transporter gene and attention deficit hyperactivity disorder
TLDR
Findings support the involvement of the dopamine system genes in ADHD liability variation, however, more work is required to further identify the functional allelic variants/mutations that are responsible for this association.
Is depression a disconnection syndrome? Meta-analysis of diffusion tensor imaging studies in patients with MDD.
TLDR
Voxel-based analysis of DTI studies of patients with MDD consistently identified decreased fractional anisotropy in the white matter fascicles connecting the prefrontal cortex within cortical (frontal, temporal and occipital lobes) and subcortical areas (amygdala and hippocampus).
Neurological soft signs are not "soft" in brain structure and functional networks: evidence from ALE meta-analysis.
TLDR
The findings from both sMRI and fMRI meta-analyses further support the conceptualization of NSS as a manifestation of the "cerebello-thalamo-prefrontal" brain network model of schizophrenia and related psychotic disorders.
Brain anatomical abnormalities in high-risk individuals, first-episode, and chronic schizophrenia: an activation likelihood estimation meta-analysis of illness progression.
TLDR
Frontotemporal brain structural abnormalities are evident in nonpsychotic individuals at high risk of developing schizophrenia and gray matter abnormalities become more extensive through first-episode and chronic illness, indicating schizophrenia appears to be a progressive cortico-striato-thalamic loop disorder.
Short-term effects of antipsychotic treatment on cerebral function in drug-naive first-episode schizophrenia revealed by "resting state" functional magnetic resonance imaging.
  • S. Lui, Tao Li, Q. Gong
  • Psychology, Medicine
    Archives of general psychiatry
  • 1 August 2010
TLDR
It is demonstrated for the first time, to the knowledge, that widespread increased regional synchronous neural activity occurs after antipsychotic therapy, accompanied by decreased integration of function across widely distributed neural networks.
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