• Publications
  • Influence
Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors.
TLDR
This review will focus on the group I mGlu receptors, a subgroup of receptors that is widely and differentially expressed in neuronal and glial cells within the brain, and receptor activation has been implicated in the control of an array of key signalling events. Expand
Non-visual GRKs: are we seeing the whole picture?
TLDR
Recent work has indicated roles for the other, non-visual GRKs and has revealed potential phosphorylation-independent regulation of GPCRs by GRK2 and GRK3, which is reviewed to attempt to put it into context withGRKs as physiological regulators that could be appropriate targets for future pharmacological intervention. Expand
Group‐I metabotropic glutamate receptors, mGlu1a and mGlu5a, couple to extracellular signal‐regulated kinase (ERK) activation via distinct, but overlapping, signalling pathways
TLDR
Findings demonstrate that, although expressed in a common cell background, these closely related mGlu receptors utilize different G proteins to cause ERK activation and may recruit different tyrosine kinases to facilitate this response. Expand
Neuronal Ca2+ stores: activation and function
TLDR
Two mechanisms of release of Ca2+ enable considerable temporal and spatial complexity of increases in the [Ca2+]i via multiple interactions at the level of intracellular-receptor activation, which underlie mechanisms that are central to information transfer and integration within neuronal compartments. Expand
Differential Regulation of Muscarinic Acetylcholine Receptor-sensitive Polyphosphoinositide Pools and Consequences for Signaling in Human Neuroblastoma Cells*
TLDR
The basal turnover of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and M3-muscarinic receptor-mediated changes in phosphoinositides in the human neuroblastoma cell line, SH-SY5Y is quantitatively assessed. Expand
Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes.
TLDR
The tissue distribution of phosphodiesterase isoenzymes is compared and the differential effects of inhibition of particular isoenZymes, with differing subcellular localization, on tissue function are discussed. Expand
Biochemical adaptation in the skeletal muscle of rats depleted of creatine with the substrate analogue beta-guanidinopropionic acid.
TLDR
It is concluded that fast-twitch muscles adapt by a combination of decreasing diffusion distances, increasing aerobic capacity and decreasing glycolytic potential, and that fibre-type-specific thresholds exist for the transformation response. Expand
Nitric Oxide Is a Volume Transmitter Regulating Postsynaptic Excitability at a Glutamatergic Synapse
TLDR
It is concluded that NO serves as a volume transmitter and slow dynamic modulator, integrating spontaneous and evoked neuronal firing, thereby providing an index of global activity and regulating information transmission across a population of active and inactive neurons. Expand
Determinants of Metabotropic Glutamate Receptor-5-mediated Ca2+ and Inositol 1,4,5-Trisphosphate Oscillation Frequency
TLDR
A single receptor can stimulate two types of InsP3-mediated Ca2+ signal dependent upon feedback inhibition, producing two distinct means of controlling the final pattern of Ca2- i release. Expand
New developments in the molecular pharmacology of the myo-inositol 1,4,5-trisphosphate receptor.
TLDR
Recent developments in IP3 receptor pharmacology are reviewed, with particular emphasis on ligand molecular recognition by this receptor-channel complex, and the potential for designing non-inositol phosphate-based agonists and antagonists is discussed. Expand
...
1
2
3
4
5
...