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Macrocyclic MR contrast agents: evaluation of multiple-organ gadolinium retention in healthy rats
TLDR
Less Gd is retained in the brain and body tissues of rats 28 days after the last exposure to ProHance® compared to other macrocyclic GBCAs, likely due to unique physico-chemical features that facilitate more rapid and efficient clearance.
High-performance liquid chromatographic assay of the X-ray contrast agent iopiperidol in plasma and urine of rats and humans.
TLDR
An HPLC method based on the reversed-phase chromatographic separation of iopiperidol and the internal standard from the endogenous components of the biological fluids, and their detection by UV absorption at 244 nm was satisfactory.
Non‐clinical assessment of safety and gadolinium deposition after cumulative administration of gadobenate dimeglumine (MultiHance®) to neonatal and juvenile rats
TLDR
Gadolinium presence in juvenile rat brain following single or repeated MultiHance administrations was minimal and non‐impactful.
High-performance liquid chromatographic determination of the magnetic resonance imaging contrast agent gadobenate ion in plasma, urine, faeces, bile and tissues.
TLDR
An HPLC method based on the reversed-phase chromatographic separation of gadobenate ion from the endogenous components of biological matrices and detection by UV absorption at 210 nm was satisfactory and the selectivity was satisfactory.
EPCglobal Standards in the Pharmaceutical Industry: Toward a Safe and Secure Supply Chain
TLDR
The article identifies areas other than counterfeit that may benefit from the standards that are being developed today and touches on issues such as patient privacy, item identification, sensor technology.
High-performance liquid chromatographic determination of the magnetic resonance imaging contrast agent Gadocoletate ion in human plasma, urine and faeces.
TLDR
The results of dedicated studies showed that Gadocoletate ion is stable in human plasma samples when stored at +4 degrees C for up to 30 days and at -80 degrees CFor up to 90 days.
High-performance liquid chromatographic determination of the X-ray imaging contrast agent, iofratol, in plasma and urine.
Iofratol is currently under evaluation as a potential X-ray contrast medium for angiography and myelography. An HPLC method for assaying iofratol in rat and human plasma and urine samples is